Harry Janssen, PhD, MD

Dr. Janssen has coordinated two lines of research over the last several years.
  • Strategies to identify immune control and disease remission in chronic viral hepatitis
    In this research area, Dr. Janssen investigates which virus and host-related conditions are required for immunological control of viral hepatitis B (HBV) and C (HCV), and in parallel, for sustained response to antiviral therapy. Large-scale multicentre clinical HBV and HCV intervention studies were combined with ancillary fundamental studies using an intensive translational approach. Clinical studies on the natural history and outcome of medical interventions of chronic viral hepatitis were mostly investigator-initiated. In 2001 Dr. Janssen was awarded a ZonMW Clinical Fellowship, in 2004 a ZonMW VIDI grant, and in 2008 European grant (VIRGIL, 6th framework) to unravel the immunological mechanism of disease chronicity and response to antiviral therapy in viral hepatitis B and C. Currently he is the Principal Investigator of the Hepatitis B Research Network (HBRN) funded by the National Institutes of Health (NIH).
  • Hypercoagulability and liver disease
    During his time at the University of Leiden (1998), Dr. Janssen studied on a national level the etiology of thrombosis of the hepatic vasculature. This was a starting point for European large-scale patient-based cohort studies to elucidate the multifactorial aetiology, the prognostic factors and the efficacy of the various treatment modalities for these life-threatening disorders. In 2001, Dr. Janssen founded the European Network for Vascular Disorders of the Liver (En-Vie), a consortium of expert centres from 9 European countries. He received a grant from the European Community (5th framework) to set up national networks, an on-line common database to federate tissue sample banks.

    Activities for these research lines resulted in an extensive scientific network, numerous high impact papers and abstracts that were presented at scientific meetings of the American Association for the Study of Liver Diseases during the past five years (2008-2012).
  • Future research
    Dr. Janssen's track record in research on the immune reactivity and long-term outcome of chronic viral hepatitis is a strong basis for future clinical and translational research at the University Health Network (UHN), which hosts the largest liver clinic in North America (Toronto Western Hospital & Toronto General Hospital).

    Dr. Janssen is enhancing UHN's Liver Disease Research Program by establishing his own clinical trial and clinical translational research programs, and obtaining financial support for these endeavors from peer review granting agencies and/or industrial partners. More concretely, he intends to initiate coordination of large scale investigator-initiated clinical research on viral hepatitis, autoimmune liver disease and liver cancer. With the number of liver patients in the Greater Toronto Area and, with the large knowledge and infrastructure for hepatology available at UHN, Dr. Janssen hopes this goal can be achieved within 3 years. He also intends to further unravel at a mechanistic level, the relationship between immune reactivity and the disease progression of various liver diseases, by founding a Liver Lab with combined laboratory space and shared common equipment and facilities for fundamental and translational liver research.
Lancet Gastroenterol Hepatol. 2018 Sep 28;:
van Tilborg M, Al Marzooqi SH, Wong WWL, Maan R, Vermehren J, Maasoumy B, Mazzulli T, Bolotin S, Garber G, Guerra F, Flud CR, Kowgier M, Janssen HL, de Knegt RJ, Pawlotsky JM, Cloherty GA, Duarte-Rojo A, Sarrazin C, Wedemeyer H, Feld JJ
Clin Gastroenterol Hepatol. 2018 Sep 27;:
Younossi ZM, Stepanova M, Younossi I, Pan CQ, Janssen HLA, Papatheodoridis G, Nader F
J Viral Hepat. 2018 Sep 05;:
van Campenhout MJH, Brouwer WP, Xie Q, Guo S, Chi H, Qi X, Tabak F, Streinu-Cercel A, Wang JY, Zhang N, Idilman R, Reesink HW, Diculescu M, Simon K, Akdogan M, Mazur W, de Knegt RJ, Verhey E, Hansen BE, Janssen HLA, ARES Study Group
Hepatology. 2018 Aug 28;:
Muir AJ, Levy C, Janssen HLA, Montano-Loza AJ, Shiffman ML, Caldwell S, Luketic V, Ding D, Jia C, McColgan BJ, McHutchison JG, Subramanian GM, Myers RP, Manns M, Chapman R, Afdhal NH, Goodman Z, Eksteen B, Bowlus CL, GS-US-321-0102 Investigators
Biomed Pharmacother. 2018 Sep;105:1147-1154
Jiang XM, Yu XN, Liu TT, Zhu HR, Shi X, Bilegsaikhan E, Guo HY, Song GQ, Weng SQ, Huang XX, Dong L, Janssen HLA, Shen XZ, Zhu JM
Hepatol Res. 2018 Jun 20;:
Hu T, Sun D, Zhang J, Xue R, Janssen HLA, Tang W, Dong L
Clin Gastroenterol Hepatol. 2018 Jun 11;:
Chi H, Li Z, Hansen BE, Yu T, Zhang X, Sun J, Hou J, Janssen HLA, Peng J
Tohoku J Exp Med. 2018;245(2):89-98
Zhu HR, Huang RZ, Yu XN, Shi X, Bilegsaikhan E, Guo HY, Song GQ, Weng SQ, Dong L, Janssen HLA, Shen XZ, Zhu JM
Nat Rev Dis Primers. 2018 Jun 07;4:18035
Yuen MF, Chen DS, Dusheiko GM, Janssen HLA, Lau DTY, Locarnini SA, Peters MG, Lai CL
J Hepatol. 2018 Apr;68(4):672-681
Agarwal K, Brunetto M, Seto WK, Lim YS, Fung S, Marcellin P, Ahn SH, Izumi N, Chuang WL, Bae H, Sharma M, Janssen HLA, Pan CQ, Çelen MK, Furusyo N, Shalimar D, Yoon KT, Trinh H, Flaherty JF, Gaggar A, Lau AH, Cathcart AL, Lin L, Bhardwaj N, Suri V,...

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Professor, Department of Medicine, University of Toronto
Head, University Health Network Liver Clinic