The central focus of the lab is protein misfolding and disease. The inability of cellular machinery to clear misfolded proteins is a recurring theme in many diseases that run the gamut from ALS to cancer. We are concentrating on AL amyloidosis in multiple myeloma, amyotrophic lateral sclerosis, and transthyretin amyloidosis disease. Our research endeavors involve two approaches. First, we have developed a novel technique to investigate microscopic pathologic anomalies seen in neurodegeneration. Second, we have utilized protein structure-based antigen design to produce therapeutic/diagnostic antibodies for ALS, TTR amyloidosis and AL amyloidosis in multiple myeloma.