The Princess Margaret Living Biobank (PMLB) offers Patient Derived tumor Organoid (PDO) and Xenograft (PDX) models and associated turnkey services for research studies.
Dr. Ming-Sound Tsao
Dr. Niki Radulovich (Core Organoid)
Dr. Nhu-An Pham (Core PDX)
For more information please continue to our website: Livingbiobank.ca
Supporting UHN Facilities
- Animal Resources Centre
- Biospecimen Sciences Program
- PM Genomics Centre
- Bioinformatics Core
- DDP-AMPL Biomarker Lab
- Advanced Optinal Microscopy Facility
- Technology Development & Commercialization
A PDO is a three-dimensional structure grown from cancer cells in a gel-like compound using media containing components which support renewal. PDOs are amenable to faster expansion times in culture under the appropriate conditions and result in higher throughput compared to PDX models.
A PDX is created when tissue/cells from a patient’s tumor is implanted directly into an immunodeficient mouse host. Once established as a xenograft model, the tumor specimen is extracted, divided and further expanded in multiple mice for cryobanking and experimentation.