The Princess Margaret Living Biobank (PMLB) offers Patient Derived tumor Organoid (PDO) and Xenograft (PDX) models and associated turnkey services for research studies.

Our Team

Scientific Director
Dr. Ming-Sound Tsao

Scientific Managers
Dr. Niki Radulovich (Core Organoid)
Dr. Nhu-An Pham (Core PDX)
 

For more information please continue to our website: Livingbiobank.ca


Supporting UHN Facilities

  • Animal Resources Centre
  • Biospecimen Sciences Program
  • PM Genomics Centre
  • Bioinformatics Core
  • DDP-AMPL Biomarker Lab
  • Advanced Optinal Microscopy Facility
  • Technology Development & Commercialization

 

Organoid Core

A PDO is a three-dimensional structure grown from cancer cells in a gel-like compound using media containing components which support renewal. PDOs are amenable to faster expansion times in culture under the appropriate conditions and result in higher throughput compared to PDX models.

More information on available Organoids.

PDX Core

A PDX is created when tissue/cells from a patient’s tumor is implanted directly into an immunodeficient mouse host. Once established as a xenograft model, the tumor specimen is extracted, divided and further expanded in multiple mice for cryobanking and experimentation. 

More information on available PDO and PDX models.

Contacts
News & Publications

The Princess Margaret Living Biobank (PMLB) offers Patient Derived tumor Organoid (PDO) and Xenograft (PDX) models and associated turnkey services for research studies.

Contacts