Clinical Genomics Centre (CGC)

CGC offers cost-effective, high throughput genotyping & sequencing services. The facility is led by Dr. Katherine Siminovitch.

Overview
  • Full service genomics technology provider - provides a broad range of services from upstream study design and grant writing support through to downstream data analysis
  • All scales of genomic analyses, from a few SNPs in a few samples to millions of SNPs in thousands of samples
  • Instrumentation includes: Illumina HiSeq2500, MiSeq and iScan; Affymetrix GeneChip and GeneTitan Systems; Sequenom MassARRAY; ABI PRISM® 7900HT; and Applied Biosystems 3730xl and 3130xl DNA Analyzers
Unique Capacities
  • With its comprehensive technology portfolio and exceptional diversity in each technology platform, the CGC enables optimal capacity, economy, efficiency, flexibility and agility
  • Fully automated sample handling and processing is performed by advanced robotics where applicable
  • Cost-effective high throughput polymorphism identification and genotyping. Extensive expertise in various aspects of sequencing, genotyping, and statistics and bioinformatics analyses
  • Fast turnaround time
Services
Next generation sequencing (NGS)
  • Sequencing and Resequencing – from targeted regions to whole genomes
  • ChIP-Sequencing (ChIP-Seq)
  • Whole Transcriptome Analysis (RNA-Seq)
  • Small RNA Discovery and Analysis

Multiplex SNP Genotyping
  • Custom designed multiplex SNP assays to reduce costs and genotype up to 40 SNPs/reaction
  • Ideally suited for fine mapping & Genome Wide Association Studies (GWAS) follow-up, which allows array-based analysis of up to 4.5 million markers

DNA Methylation Analysis
  • Automatic discovery and quantitation of multiple methylated CpG positions
  • Cost effective for small and large numbers of samples, with a few or numerous amplicons per sample

Conventional Sanger Sequencing
  • From single tube to high-throughput plate format

DNA/RNA sample purification from blood/saliva/swab samples

Establishment of transformed cell lines from blood lymphocytes
Using the Facility
  • Facility accessible to all the academic and industrial users
  • No selection process
  • Fee for service

Sample Preparation
For more information visit: http://clinicalgenomics.ca.
Quick Links
Contacts

Dr. Aaron Goldman
Director of Genomics Services
416-586-4800 (ext 7654)
www.clinicalgenomics.ca

 

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CGC offers cost-effective, high throughput genotyping & sequencing services. The facility is led by Dr. Katherine Siminovitch.

Overview
  • Full service genomics technology provider - provides a broad range of services from upstream study design and grant writing support through to downstream data analysis
  • All scales of genomic analyses, from a few SNPs in a few samples to millions of SNPs in thousands of samples
  • Instrumentation includes: Illumina HiSeq2500, MiSeq and iScan; Affymetrix GeneChip and GeneTitan Systems; Sequenom MassARRAY; ABI PRISM® 7900HT; and Applied Biosystems 3730xl and 3130xl DNA Analyzers
Unique Capacities
  • With its comprehensive technology portfolio and exceptional diversity in each technology platform, the CGC enables optimal capacity, economy, efficiency, flexibility and agility
  • Fully automated sample handling and processing is performed by advanced robotics where applicable
  • Cost-effective high throughput polymorphism identification and genotyping. Extensive expertise in various aspects of sequencing, genotyping, and statistics and bioinformatics analyses
  • Fast turnaround time
Services
Next generation sequencing (NGS)
  • Sequencing and Resequencing – from targeted regions to whole genomes
  • ChIP-Sequencing (ChIP-Seq)
  • Whole Transcriptome Analysis (RNA-Seq)
  • Small RNA Discovery and Analysis

Multiplex SNP Genotyping
  • Custom designed multiplex SNP assays to reduce costs and genotype up to 40 SNPs/reaction
  • Ideally suited for fine mapping & Genome Wide Association Studies (GWAS) follow-up, which allows array-based analysis of up to 4.5 million markers

DNA Methylation Analysis
  • Automatic discovery and quantitation of multiple methylated CpG positions
  • Cost effective for small and large numbers of samples, with a few or numerous amplicons per sample

Conventional Sanger Sequencing
  • From single tube to high-throughput plate format

DNA/RNA sample purification from blood/saliva/swab samples

Establishment of transformed cell lines from blood lymphocytes
Using the Facility
  • Facility accessible to all the academic and industrial users
  • No selection process
  • Fee for service

Sample Preparation
For more information visit: http://clinicalgenomics.ca.
Quick Links
Contacts

Dr. Aaron Goldman
Director of Genomics Services
416-586-4800 (ext 7654)
www.clinicalgenomics.ca