W Mark Erwin

W Mark Erwin, PhD, DC

My research programme is directed along a restorative/regenerative medicine theme principally concerning interactions between cells within the intervertebral disc (IVD). My laboratory has demonstrated in vitro and in vivo activity of pluripotent stem cells obtained from within the nucleus as well as extracellular matrix protective/anti-apoptotic effects of notochordal cells sourced from within the IVD.

My laboratory collaborates with Drs. Michael Fehlings, Charles Tator, Florence Tsui, Robert Inman at UHN, the UHN microarray facility, Drs. David Brigstock at National Children's Hospital and Ohio State University, and Dr. Michael Siu's mass spectroscopy group at York University.

I teach within the orthopaedic and neurosurgical residency programme (intervertebral disc biology and non-operative rehabilitation of spinal pain syndromes) and have given several seminars within the divisions of orthopaedic and neurosurgery. I am an active member of a number of scientific societies including the biologics committee with the North American Spine Society and am a member of the University of Toronto Spine Programme executive committee.

Vision Statement:
To develop a collaborative, translationally focused restorative/regenerative medicine research programme with a specific interest in degenerative disease affecting the spine.
Spine J. 2017 Jan 09;:
Mehrkens A, Matta A, Karim MZ, Kim S, Fehlings MG, Schaeren S, Erwin WM
Chiropr Man Therap. 2016;24(1):33
Emary PC, Houweling TA, Wangler M, Burnie SJ, Hood KJ, Erwin WM
Arthritis Res Ther. 2016;18(1):125
Müller S, Acevedo L, Wang X, Karim MZ, Matta A, Mehrkens A, Schaeren S, Feliciano S, Jakob M, Martin I, Barbero A, Erwin WM
Arthritis Res Ther. 2015;17(1):240
Erwin WM, DeSouza L, Funabashi M, Kawchuk G, Karim MZ, Kim S, Mӓdler S, Matta A, Wang X, Mehrkens KA
J Can Chiropr Assoc. 2014 Sep;58(3):246-57
Erwin WM, Hood KE
Nucleic Acids Res. 2014;42(10):6673-85
Neumann P, Lakomek K, Naumann PT, Erwin WM, Lauhon CT, Ficner R
Evid Based Spine Care J. 2013 Oct;4(2):154-6
Mehrkens A, Karim MZ, Kim S, Hilario R, Fehlings MG, Erwin WM
J Can Chiropr Assoc. 2013 Dec;57(4):285-91
Erwin WM, Korpela AP, Jones RC



Assistant Professor, Department of Surgery, Divisions of Orthopaedic and Neurological Surgery, University of Toronto

Faculty, Divisions of Orthopaedic and Neurosurgery, University of Toronto