The Kislinger Laboratory is located at the Princess Margaret Cancer Research Tower of the Princess Margaret Cancer Centre, the largest oncology treatment and research facility in Canada. The major goal of our lab is to apply proteomics technologies to cancer and cardiovascular research. Our research interests include technology development, using the latest generation of mass spectrometry instrumentation, basic cell biology and translational cancer research.
In-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome.
Biochem Biophys Res Commun. 2014 Mar 21;445(4):694-701
Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state.
Exp Cell Res. 2013 Oct 15;319(17):2747-57
Genome Med. 2013;5(6):56
Proteomics. 2013 May;13(10-11):1551-3
Proteomics. 2013 May;13(10-11):1667-71
Tumor-derived exosomes and microvesicles in head and neck cancer: implications for tumor biology and biomarker discovery.
Proteomics. 2013 May;13(10-11):1608-23
Cell Death Differ. 2013 Jun;20(6):812-22
A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation.
PLoS Genet. 2012;8(11):e1003047
Cancer cells induced to express mesenchymal phenotype release exosome-like extracellular vesicles carrying tissue factor.
J Biol Chem. 2012 Dec 21;287(52):43565-72
Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer.
Mol Cell Proteomics. 2012 Dec;11(12):1870-84
Senior Scientist, Princess Margaret Cancer Centre