Shereen Ezzat, MD, FACP, FRCPC

Our lab studies the mechanisms of cancer development in hormone-producing glands (endocrine tumours) including those arising from the thyroid, pituitary, endocrine pancreas and adrenal glands.

We are interested in the mechanisms leading to the transcriptional and epigenetic regulation of tumour-derived growth and survival signals. Our focus is on members of the fibroblast growth factor (FGF) family of receptor tyrosine kinases which play an important role in sporadic and familial forms of these diseases. Signalling emphasis is on non-classical heterophilic interactions with cell adhesion molecules.
J Clin Med. 2018 Sep 13;7(9):
Asa SL, Ezzat S, Mete O
Endocr Pathol. 2018 Sep 13;:
Mete O, Alshaikh OM, Cintosun A, Ezzat S, Asa SL
Int J Radiat Oncol Biol Phys. 2018 Oct 01;102(2):340-352
McDowell LJ, Rock K, Xu W, Chan B, Waldron J, Lu L, Ezzat S, Pothier D, Bernstein LJ, So N, Huang SH, Giuliani M, Hope A, O'Sullivan B, Bratman SV, Cho J, Kim J, Jang R, Bayley A, Ringash J
Psychooncology. 2018 Aug 13;:
Sawka AM, Watt S, Rodin G, Ezzat S, Howell D, Tsang RW, Brierley JD, Krzyzanowska MK, Goldstein D, Li M
Nat Genet. 2018 Jun 18;:
Alvarez MJ, Subramaniam PS, Tang LH, Grunn A, Aburi M, Rieckhof G, Komissarova EV, Hagan EA, Bodei L, Clemons PA, Dela Cruz FS, Dhall D, Diolaiti D, Fraker DA, Ghavami A, Kaemmerer D, Karan C, Kidd M, Kim KM, Kim HC, Kunju LP, Langel Ü, Li Z, Lee J, Li...
Onco Targets Ther. 2018;11:3179-3184
Duan M, Xing H, Wang K, Niu C, Jiang C, Zhang L, Ezzat S, Zhang L
Onco Targets Ther. 2017;10:5459-5462
Zhang L, Zhang C, Yang Z, He M, Zhang L, Ezzat S, Liang X
J Surg Oncol. 2017 Sep 10;:
Samuel N, Ejaz R, Silver J, Ezzat S, Cusimano RJ, Kim RH



Endocrine Oncology Site Group Head, Toronto General Hospital​
Professor, Medicine and Oncology, University of Toronto​