Dr. Ryan Dowling is an Affiliate Scientist at the Princess Margaret Cancer Centre. He earned his Bachelor of Science (2001) and Master of Science (2004) degrees from the University of Guelph and completed his Ph.D. in biochemistry (2009) at McGill University in the laboratory of Dr. Nahum Sonenberg. His research at McGill focused on the role of mTOR signalling in translational control and the anti-cancer effects of metformin, a common drug used for the treatment of diabetes.
After completion of his Ph.D., Ryan pursued postdoctoral training under the supervision of Dr. Vuk Stambolic at the Princess Margaret Cancer Centre where he was awarded a CIHR Banting Postdoctoral Fellowship. His work with Dr. Stambolic involved characterizing the clinical and biological effects of metformin in human breast cancer patients and assessing the role of the insulin receptor in obesity-associated cancers. In 2016, Ryan became an Affiliate Scientist at the Princess Margaret Cancer Centre where he continues to focus on insulin receptor signalling in human cancer using basic techniques in molecular biology as well as patient material from clinical trials.