My research interest is the clinical significance of somatic and inherited genetic alterations in colorectal cancer. These include the relationship of genetic events to the risk of developing cancer, cancer prognosis and response to treatment. In addition, I am currently pursuing chemical genetic approaches for development of novel cancer therapies.
Eur J Surg Oncol. 2016 Jul 27;
High prevalence of adenomatous colorectal polyps in young cancer survivors treated with abdominal radiation therapy: results of a prospective trial.
Gut. 2016 Jul 13;
DNA Mismatch Repair Status Predicts Need for Future Colorectal Surgery for Metachronous Neoplasms in Young Individuals Undergoing Colorectal Cancer Resection.
Dis Colon Rectum. 2015 Jul;58(7):645-52
Proctocolectomy for colorectal cancer-is the ileal pouch anal anastomosis a safe alternative to permanent ileostomy?
Int J Colorectal Dis. 2014 Oct 17;
Family history of colorectal cancer is not associated with colorectal cancer survival regardless of microsatellite instability status.
Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1700-4
Hereditary colorectal cancer registries in Canada: report from the Colorectal Cancer Association of Canada consensus meeting; Montreal, Quebec; October 28, 2011.
Curr Oncol. 2013 Oct;20(5):273-8
Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.
Int J Cancer. 2014 May 15;134(10):2330-41
Colon and rectal cancer survival by tumor location and microsatellite instability: the Colon Cancer Family Registry.
Dis Colon Rectum. 2013 Aug;56(8):937-44
Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.
Genes Chromosomes Cancer. 2013 May;52(5):450-66
Int J Colorectal Dis. 2013 Sep;28(9):1313-4
Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre
Colorectal Surgical Oncologist, Princess Margaret Hospital
Colorectal Surgeon, Zane Cohen Centre, Mount Sinai Hospital
Researcher, Lunenfeld-Tanenbaum Research Institute