Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry.
ACS Infect Dis. 2018 Feb 13;:
Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii.
J Med Chem. 2017 Sep 21;:
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
Nat Commun. 2017 Sep 05;8(1):430
Pembrolizumab as first-line therapy for patients with PD-L1-positive advanced non-small cell lung cancer: a phase 1 trial.
Ann Oncol. 2017 Feb 07;:
Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.
Bioorg Med Chem. 2017 Jan 24;:
Angew Chem Int Ed Engl. 2016 Dec 14;:
ACS Infect Dis. 2016 Mar 11;2(3):194-206
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
PLoS One. 2016;11(3):e0149996
J Biol Chem. 2016 Mar 1;
Biochemical characterization of FIKK8 - A unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans.
Mol Biochem Parasitol. 2015 Jun;201(2):85-9