A salient feature of almost all cardiovascular diseases, and there associated risk factors, is the activation of the sympathetic nervous system. The consequences of this action are profound and impact blood pressure control, insulin sensitivity, arrhythmogenesis, and risk of sudden cardiac death. The primary aim of my research is to better understand the mechanisms that control and the functional consequences of sympathetic outflow at rest and during stress in humans with and without cardiovascular disease. To elucidate these mechanisms, I employ direct intraneural recordings of postganglionic sympathetic nerve activity, studying both multi- and single-fibre preparations. A major focus of my current work is directed at uncovering the ability of sympathetic fibres to be selectively and differentially controlled. Advancing our knowledge of these integrative mechanisms will open the doors to testing novel and clinically relevant exercise and non-exercise interventions designed to reduce sympathetic over-activation. Presently, my research is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Canada Foundation for Innovation (CFI).