A salient feature of almost all cardiovascular diseases, and there associated risk factors, is the activation of the sympathetic nervous system. The consequences of this action are profound and impact blood pressure control, insulin sensitivity, arrhythmogenesis, and risk of sudden cardiac death. The primary aim of my research is to better understand the mechanisms that control and the functional consequences of sympathetic outflow at rest and during stress in humans with and without cardiovascular disease. To elucidate these mechanisms, I employ direct intraneural recordings of postganglionic sympathetic nerve activity, studying both multi- and single-fibre preparations. A major focus of my current work is directed at uncovering the ability of sympathetic fibres to be selectively and differentially controlled. Advancing our knowledge of these integrative mechanisms will open the doors to testing novel and clinically relevant exercise and non-exercise interventions designed to reduce sympathetic over-activation. Presently, my research is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Canada Foundation for Innovation (CFI).
J Physiol. 2018 Sep 11;:
Pharmacological assessment of the arterial baroreflex in a young healthy obese male with extremely low baseline muscle sympathetic nerve activity.
Clin Auton Res. 2018 Aug 20;:
Med Sci Sports Exerc. 2018 Aug 10;:
MICRONEUROGRAPHIC CHARACTERIZATION OF SYMPATHETIC RESPONSES DURING 1-LEG EXERCISE IN YOUNG AND MIDDLE-AGED HUMANS.
Appl Physiol Nutr Metab. 2018 Jul 31;:
Hypertensive Response With Exercise to Reveal Increased Cardiovascular Risk in Adults With Aortic Coarctation Repair: Value and Caution.
Can J Cardiol. 2018 May;34(5):536-539
Heart Rate Variability Responses of Individuals With and Without Saline-Induced Obstructive Sleep Apnea.
J Clin Sleep Med. 2018 Apr 15;14(4):503-510
Moderate and severe hypoxia elicit divergent effects on cardiovascular function and physiological rhythms.
J Physiol. 2018 Mar 31;:
Heritability and genetic correlations of heart rate variability at rest and during stress in the Oman Family Study.
J Hypertens. 2018 Jul;36(7):1477-1485
Comparison of laboratory and ambulatory measures of central blood pressure and pulse wave reflection: hitting the target or missing the mark?
J Am Soc Hypertens. 2018 Apr;12(4):275-284
J Am Heart Assoc. 2018 Jan 29;7(3):
Affiliate Scientist, Toronto General Hospital Research Institute (TGHRI)
Assistant Professor, Human Health & Nutritional Sciences, University of Guelph
Adjunct faculty, School of Health and Human Performance, Dalhousie University