Philip J Millar

Philip J Millar

A salient feature of almost all cardiovascular diseases, and there associated risk factors, is the activation of the sympathetic nervous system. The consequences of this action are profound and impact blood pressure control, insulin sensitivity, arrhythmogenesis, and risk of sudden cardiac death. The primary aim of my research is to better understand the mechanisms that control and the functional consequences of sympathetic outflow at rest and during stress in humans with and without cardiovascular disease. To elucidate these mechanisms, I employ direct intraneural recordings of postganglionic sympathetic nerve activity, studying both multi- and single-fibre preparations. A major focus of my current work is directed at uncovering the ability of sympathetic fibres to be selectively and differentially controlled. Advancing our knowledge of these integrative mechanisms will open the doors to testing novel and clinically relevant exercise and non-exercise interventions designed to reduce sympathetic over-activation. Presently, my research is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Canada Foundation for Innovation (CFI).
Am J Physiol Regul Integr Comp Physiol. 2017 Oct 25;:ajpregu.00266.2017
Incognito AV, Doherty CJ, Lee JB, Burns MJ, Millar PJ
Am J Physiol Heart Circ Physiol. 2017 Sep 22;:ajpheart.00494.2017
Doherty CJ, Incognito AV, Notay K, Burns MJ, Slysz JT, Seed JD, Nardone M, Burr JF, Millar PJ
Am J Physiol Heart Circ Physiol. 2017 Jul 01;313(1):H59-H65
Notay K, Incognito AV, Millar PJ
Front Neurosci. 2016;10:568
Strzalkowski ND, Incognito AV, Bent LR, Millar PJ
J Appl Physiol (1985). 2016 Nov 01;121(5):1065-1073
Notay K, Seed JD, Incognito AV, Doherty CJ, Nardone M, Burns MJ, Millar PJ
Hypertension. 2016 Dec;68(6):1467-1474
Taylor KS, Murai H, Millar PJ, Haruki N, Kimmerly DS, Morris BL, Tomlinson G, Bradley TD, Floras JS
Sports Med. 2016 Apr;46(4):531-44
Incognito AV, Burr JF, Millar PJ

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Assistant Professor, Human Health & Nutritional Sciences, University of Guelph
Adjunct faculty, School of Health and Human Performance, Dalhousie University