A salient feature of almost all cardiovascular diseases, and there associated risk factors, is the activation of the sympathetic nervous system. The consequences of this action are profound and impact blood pressure control, insulin sensitivity, arrhythmogenesis, and risk of sudden cardiac death. The primary aim of my research is to better understand the mechanisms that control and the functional consequences of sympathetic outflow at rest and during stress in humans with and without cardiovascular disease. To elucidate these mechanisms, I employ direct intraneural recordings of postganglionic sympathetic nerve activity, studying both multi- and single-fibre preparations. A major focus of my current work is directed at uncovering the ability of sympathetic fibres to be selectively and differentially controlled. Advancing our knowledge of these integrative mechanisms will open the doors to testing novel and clinically relevant exercise and non-exercise interventions designed to reduce sympathetic over-activation. Presently, my research is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Canada Foundation for Innovation (CFI).
J Physiol. 2019 Aug 01;:
Training Heart Failure Patients with Reduced Ejection Fraction Attenuates Muscle Sympathetic Nerve Activation During Mild Dynamic Exercise.
Am J Physiol Regul Integr Comp Physiol. 2019 Jul 31;:
Effects of dynamic arm and leg exercise on muscle sympathetic nerve activity and vascular conductance in the inactive leg.
J Appl Physiol (1985). 2019 Jun 27;:
Simultaneous assessment of central and peripheral chemoreflex regulation of muscle sympathetic nerve activity and ventilation in healthy young men.
J Physiol. 2019 May 13;:
Heart Failure-Specific Relationship Between Muscle Sympathetic Nerve Activity and Aortic Wave Reflection.
J Card Fail. 2019 Mar 09;:
J Appl Physiol (1985). 2019 Feb 28;:
Docosahexaenoic acid reduces resting blood pressure but increases muscle sympathetic outflow compared to eicosapentaenoic acid in healthy men and women.
Am J Physiol Heart Circ Physiol. 2019 Feb 08;:
Front Physiol. 2018;9:1700
Evidence for differential control of muscle sympathetic single units during mild sympathoexcitation in young healthy humans.
Am J Physiol Heart Circ Physiol. 2018 Nov 02;:
Cardiovascular responses during isometric exercise following lengthening and shortening contractions.
J Appl Physiol (1985). 2018 Nov 01;:
Affiliate Scientist, Toronto General Hospital Research Institute (TGHRI)
Assistant Professor, Human Health & Nutritional Sciences, University of Guelph
Adjunct faculty, School of Health and Human Performance, Dalhousie University