Philip J Millar

A salient feature of almost all cardiovascular diseases, and there associated risk factors, is the activation of the sympathetic nervous system. The consequences of this action are profound and impact blood pressure control, insulin sensitivity, arrhythmogenesis, and risk of sudden cardiac death. The primary aim of my research is to better understand the mechanisms that control and the functional consequences of sympathetic outflow at rest and during stress in humans with and without cardiovascular disease. To elucidate these mechanisms, I employ direct intraneural recordings of postganglionic sympathetic nerve activity, studying both multi- and single-fibre preparations. A major focus of my current work is directed at uncovering the ability of sympathetic fibres to be selectively and differentially controlled. Advancing our knowledge of these integrative mechanisms will open the doors to testing novel and clinically relevant exercise and non-exercise interventions designed to reduce sympathetic over-activation. Presently, my research is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Canada Foundation for Innovation (CFI).
J Physiol. 2018 Sep 11;:
Notay K, Klingel SL, Lee JB, Doherty CJ, Seed JD, Swiatczak M, Mutch DM, Millar PJ
Clin Auton Res. 2018 Aug 20;:
Incognito AV, Samora M, Cartafina RA, Guimarães GMN, Daher M, Millar PJ, Vianna LC
Med Sci Sports Exerc. 2018 Aug 10;:
Coates AM, Millar PJ, Burr JF
Appl Physiol Nutr Metab. 2018 Jul 31;:
Notarius CF, Millar PJ, Doherty CJ, Incognito AV, Haruki N, O'Donnell E, Floras JS
J Clin Sleep Med. 2018 Apr 15;14(4):503-510
Vena D, Bradley TD, Millar PJ, Floras JS, Rubianto J, Gavrilovic B, Perger E, Yadollahi A
J Physiol. 2018 Mar 31;:
Allwood MA, Edgett BA, Eadie AL, Huber JS, Romanova N, Millar PJ, Brunt KR, Simpson JA
J Hypertens. 2018 Jul;36(7):1477-1485
Muñoz ML, Jaju D, Voruganti S, Albarwani S, Aslani A, Bayoumi R, Al-Yahyaee S, Comuzzie AG, Millar PJ, Picton P, Floras JS, Nolte I, Hassan MO, Snieder H
J Am Soc Hypertens. 2018 Apr;12(4):275-284
Burns MJ, Seed JD, Incognito AV, Doherty CJ, Notay K, Millar PJ
J Am Heart Assoc. 2018 Jan 29;7(3):
Nardone M, Incognito AV, Millar PJ

Pages


Assistant Professor, Human Health & Nutritional Sciences, University of Guelph
Adjunct faculty, School of Health and Human Performance, Dalhousie University