Philip J Millar

A salient feature of almost all cardiovascular diseases, and there associated risk factors, is the activation of the sympathetic nervous system. The consequences of this action are profound and impact blood pressure control, insulin sensitivity, arrhythmogenesis, and risk of sudden cardiac death. The primary aim of my research is to better understand the mechanisms that control and the functional consequences of sympathetic outflow at rest and during stress in humans with and without cardiovascular disease. To elucidate these mechanisms, I employ direct intraneural recordings of postganglionic sympathetic nerve activity, studying both multi- and single-fibre preparations. A major focus of my current work is directed at uncovering the ability of sympathetic fibres to be selectively and differentially controlled. Advancing our knowledge of these integrative mechanisms will open the doors to testing novel and clinically relevant exercise and non-exercise interventions designed to reduce sympathetic over-activation. Presently, my research is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Canada Foundation for Innovation (CFI).
J Physiol. 2019 Aug 01;:
Incognito AV, Duplea SG, Lee JB, Sussman J, Shepherd AD, Doherty CJ, Cacoilo JA, Notay K, Millar PJ
Am J Physiol Regul Integr Comp Physiol. 2019 Jul 31;:
Notarius CF, Millar PJ, Keir DA, Murai H, Haruki N, O'Donnell E, Marzolini S, Oh P, Floras JS
J Appl Physiol (1985). 2019 Jun 27;:
Doherty CJ, King TJ, Incognito AV, Lee JB, Shepherd AD, Cacoilo JA, Slysz JT, Burr JF, Millar PJ
J Card Fail. 2019 Mar 09;:
Millar PJ, Notarius CF, Haruki N, Floras JS
J Appl Physiol (1985). 2019 Feb 28;:
Yadollahi A, Singh B, Millar PJ, Vena D, Floras JS, Bradley TD
Am J Physiol Heart Circ Physiol. 2019 Feb 08;:
Lee JB, Notay K, Klingel S, Chabowski A, Mutch DM, Millar PJ
Front Physiol. 2018;9:1700
Currie KD, Coates AM, Slysz JT, Aubry RL, Whinton AK, Mountjoy ML, Millar PJ, Burr JF
Am J Physiol Heart Circ Physiol. 2018 Nov 02;:
Incognito AV, Doherty CJ, Nardone M, Lee JB, Notay K, Seed JD, Millar PJ
J Appl Physiol (1985). 2018 Nov 01;:
Seed JD, St Peters B, Power GA, Millar PJ

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Assistant Professor, Human Health & Nutritional Sciences, University of Guelph
Adjunct faculty, School of Health and Human Performance, Dalhousie University