Peter H Backx, PhD, DVM

Our research interests focus in two main areas: the molecular structure of cardiac ion channels and the physiological role of cardiac ion channels in normal and diseased myocardium.

The ultimate goal of these studies is develop therapeutic agents to treat cardiovascular disease by targeting ion channels. Our recent results in transgenic mice suggest that alterations in cardiac ion channel function can initiate and contribute to heart disease progression.

In another set of studies we have developed a novel paradigm for the creation of tissue-specific agents for the modulation of ion channel function.
Front Physiol. 2018;9:841
Lakin R, Guzman C, Izaddoustdar F, Polidovitch N, Goodman JM, Backx PH
Appl Physiol Nutr Metab. 2018 May 29;:
Goodman JM, Banks L, Connelly KA, Yan A, Backx PH, Dorian P
PLoS One. 2018;13(5):e0197273
Liu J, Bayer JD, Aschar-Sobbi R, Wauchop M, Spears D, Gollob M, Vigmond EJ, Tsushima R, Backx PH, Chauhan VS
Cardiovasc Res. 2018 Apr 10;:
Barichello S, Roberts JD, Backx P, Boyle P, Laksman Z
Clin Sci (Lond). 2018 Feb 27;:
Sadi AM, Afroze T, Siraj MA, Momen A, White-Dzuro C, Zarrin-Khat D, Handa S, Ban K, Kabir MG, Trivieri MG, Gros R, Backx P, Husain M
Theranostics. 2017;7(16):3842-3855
Zeng Y, Du WW, Wu Y, Yang Z, Awan FM, Li X, Yang W, Zhang C, Yang Q, Yee A, Chen Y, Yang F, Sun H, Huang R, Yee AJ, Li RK, Wu Z, Backx PH, Yang BB
Cell Stem Cell. 2017 Aug 03;21(2):179-194.e4
Lee JH, Protze SI, Laksman Z, Backx PH, Keller GM
Cell Cycle. 2017 Jul 26;:0
Stanley-Hasnain S, Hauck L, Grothe D, Aschar-Sobbi R, Beca S, Butany J, Backx PH, Mak TW, Billia F
Sci Rep. 2017 Jul 13;7(1):5268
Laksman Z, Wauchop M, Lin E, Protze S, Lee J, Yang W, Izaddoustdar F, Shafaattalab S, Gepstein L, Tibbits GF, Keller G, Backx PH
Nat Commun. 2017 May 26;8:15518
Yin JC, Platt MJ, Tian X, Wu X, Backx PH, Simpson JA, Araki T, Neel BG

Pages


Professor, Departments of Physiology and Medicine, University of Toronto