Peter H Backx

Peter H Backx, PhD, DVM

Our research interests focus in two main areas: the molecular structure of cardiac ion channels and the physiological role of cardiac ion channels in normal and diseased myocardium.

The ultimate goal of these studies is develop therapeutic agents to treat cardiovascular disease by targeting ion channels. Our recent results in transgenic mice suggest that alterations in cardiac ion channel function can initiate and contribute to heart disease progression.

In another set of studies we have developed a novel paradigm for the creation of tissue-specific agents for the modulation of ion channel function.
N Engl J Med. 2008 Mar 13;358(11):1129-36
Eremina V, Jefferson JA, Kowalewska J, Hochster H, Haas M, Weisstuch J, Richardson C, Kopp JB, Kabir MG, Backx PH, Gerber HP, Ferrara N, Barisoni L, Alpers CE, Quaggin SE
Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1948-55
Borchert GH, Giggey M, Kolar F, Wong TM, Backx PH, Escriba PV
Cardiovasc Res. 2008 Jun 1;78(3):505-14
Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM
Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1675-83
Martino TA, Oudit GY, Herzenberg AM, Tata N, Koletar MM, Kabir GM, Belsham DD, Backx PH, Ralph MR, Sole MJ
Mol Cell Proteomics. 2008 Mar;7(3):519-33
Gramolini AO, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson NJ, Isserlin R, Sharma P, Oudit GY, Trivieri MG, Fagan A, Kannan A, Higgins DG, Huedig H, Hess G, Arab S, Seidman JG, Seidman CE, Frey B, Perry M, Backx PH, Liu PP, MacLennan DH, Emili A
J Hypertens. 2007 Oct;25(10):2074-81
Keszei AP, Tislér A, Backx PH, Andrulis IL, Bull SB, Logan AG
Circ Res. 2007 Aug 17;101(4):400-8
Kerfant BG, Zhao D, Lorenzen-Schmidt I, Wilson LS, Cai S, Chen SR, Maurice DH, Backx PH

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Professor, Departments of Physiology and Medicine, University of Toronto