Peter H Backx, PhD, DVM

Our research interests focus in two main areas: the molecular structure of cardiac ion channels and the physiological role of cardiac ion channels in normal and diseased myocardium.

The ultimate goal of these studies is develop therapeutic agents to treat cardiovascular disease by targeting ion channels. Our recent results in transgenic mice suggest that alterations in cardiac ion channel function can initiate and contribute to heart disease progression.

In another set of studies we have developed a novel paradigm for the creation of tissue-specific agents for the modulation of ion channel function.
Hypertension. 2010 Sep;56(3):422-9
Liang W, Oudit GY, Patel MM, Shah AM, Woodgett JR, Tsushima RG, Ward ME, Backx PH
Free Radic Biol Med. 2010 Nov 1;49(8):1306-14
Belik J, Stevens D, Pan J, McIntyre BA, Kantores C, Ivanovska J, Xu EZ, Ibrahim C, Panama BK, Backx PH, McNamara PJ, Jankov RP
Endocrinology. 2010 Apr;151(4):1520-31
Ban K, Kim KH, Cho CK, Sauvé M, Diamandis EP, Backx PH, Drucker DJ, Husain M
Am J Pathol. 2010 Mar;176(3):1113-21
Papp S, Dziak E, Kabir G, Backx P, Clement S, Opas M
Hypertension. 2009 Aug;54(2):286-93
Liang W, Ray JB, He JZ, Backx PH, Ward ME
Circ Res. 2008 Oct 24;103(9):e120
Rose RA, Keating A, Backx PH
Circ Res. 2008 Sep 12;103(6):643-53
Ban K, Cooper AJ, Samuel S, Bhatti A, Patel M, Izumo S, Penninger JM, Backx PH, Oudit GY, Tsushima RG

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Professor, Departments of Physiology and Medicine, University of Toronto