Peter H Backx, PhD, DVM

Our research interests focus in two main areas: the molecular structure of cardiac ion channels and the physiological role of cardiac ion channels in normal and diseased myocardium.

The ultimate goal of these studies is develop therapeutic agents to treat cardiovascular disease by targeting ion channels. Our recent results in transgenic mice suggest that alterations in cardiac ion channel function can initiate and contribute to heart disease progression.

In another set of studies we have developed a novel paradigm for the creation of tissue-specific agents for the modulation of ion channel function.
Circ Res. 2011 Mar 4;108(5):537-43
Panama BK, Latour-Villamil D, Farman GP, Zhao D, Bolz SS, Kirshenbaum LA, Backx PH
J Cell Mol Med. 2011 Nov;15(11):2307-16
Ye L, Zhu W, Backx PH, Cortez MA, Wu J, Chow YH, McKerlie C, Wang A, Tsui LC, Gross GJ, Hu J
Circ Res. 2011 Jan 21;108(2):184-93
Vanderlaan RD, Hardy WR, Kabir MG, Pasculescu A, Jones N, deTombe PP, Backx PH, Pawson T
Clin Sci (Lond). 2011 May;120(10):451-62
Li J, Xuan W, Yan R, Tropak MB, Jean-St-Michel E, Liang W, Gladstone R, Backx PH, Kharbanda RK, Redington AN
Cardiovasc Res. 2011 Feb 15;89(3):623-33
Mueller EE, Momen A, Massé S, Zhou YQ, Liu J, Backx PH, Henkelman RM, Nanthakumar K, Stewart DJ, Husain M
Biophys J. 2010 Nov 3;99(9):2978-86
Farman GP, Allen EJ, Schoenfelt KQ, Backx PH, de Tombe PP
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18481-6
Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO
Stroke. 2010 Nov;41(11):2618-24
Scherer EQ, Yang J, Canis M, Reimann K, Ivanov K, Diehl CD, Backx PH, Wier WG, Strieth S, Wangemann P, Voigtlaender-Bolz J, Lidington D, Bolz SS
Circ Res. 2010 Nov 12;107(10):1275-89
Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY

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Professor, Departments of Physiology and Medicine, University of Toronto