Peter H Backx, PhD, DVM

Our research interests focus in two main areas: the molecular structure of cardiac ion channels and the physiological role of cardiac ion channels in normal and diseased myocardium.

The ultimate goal of these studies is develop therapeutic agents to treat cardiovascular disease by targeting ion channels. Our recent results in transgenic mice suggest that alterations in cardiac ion channel function can initiate and contribute to heart disease progression.

In another set of studies we have developed a novel paradigm for the creation of tissue-specific agents for the modulation of ion channel function.
J Pharmacol Exp Ther. 2013 Jun;345(3):383-92
Jadhav A, Liang W, Papageorgiou PC, Shoker A, Kanthan SC, Balsevich J, Levy AS, Heximer S, Backx PH, Gopalakrishnan V
Circ Res. 2013 Jan 18;112(2):289-97
Beca S, Ahmad F, Shen W, Liu J, Makary S, Polidovitch N, Sun J, Hockman S, Chung YW, Movsesian M, Murphy E, Manganiello V, Backx PH
Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H967-78
Chis R, Sharma P, Bousette N, Miyake T, Wilson A, Backx PH, Gramolini AO
Mol Cell Biol. 2012 Oct;32(19):3872-90
Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T
Heart Rhythm. 2012 Oct;9(10):1681-1688.e1
Nair K, Pekhletski R, Harris L, Care M, Morel C, Farid T, Backx PH, Szabo E, Nanthakumar K
Circ Res. 2012 May 25;110(11):1513-24
Kim KH, Rosen A, Bruneau BG, Hui CC, Backx PH
Circulation. 2012 Jun 12;125(23):2904-13
Degousee N, Simpson J, Fazel S, Scholich K, Angoulvant D, Angioni C, Schmidt H, Korotkova M, Stefanski E, Wang XH, Lindsay TF, Ofek E, Pierre S, Butany J, Jakobsson PJ, Keating A, Li RK, Nahrendorf M, Geisslinger G, Backx PH, Rubin BB
J Immunol Methods. 2012 Feb 28;376(1-2):132-8
Papageorgiou PC, Yeo EL, Backx PH, Floras JS
Clin Sci (Lond). 2012 Jun;122(12):581-90
Papageorgiou PC, Yeo EL, Backx PH, Floras JS

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Professor, Departments of Physiology and Medicine, University of Toronto