Peter H Backx, PhD, DVM

Our research interests focus in two main areas: the molecular structure of cardiac ion channels and the physiological role of cardiac ion channels in normal and diseased myocardium.

The ultimate goal of these studies is develop therapeutic agents to treat cardiovascular disease by targeting ion channels. Our recent results in transgenic mice suggest that alterations in cardiac ion channel function can initiate and contribute to heart disease progression.

In another set of studies we have developed a novel paradigm for the creation of tissue-specific agents for the modulation of ion channel function.
Proc Natl Acad Sci U S A. 2015 Apr 15;
Chung YW, Lagranha C, Chen Y, Sun J, Tong G, Hockman SC, Ahmad F, Esfahani SG, Bae DH, Polidovitch N, Wu J, Rhee DK, Lee BS, Gucek M, Daniels MP, Brantner CA, Backx PH, Murphy E, Manganiello VC
Nat Commun. 2015;6:6018
Aschar-Sobbi R, Izaddoustdar F, Korogyi AS, Wang Q, Farman GP, Yang F, Yang W, Dorian D, Simpson JA, Tuomi JM, Jones DL, Nanthakumar K, Cox B, Wehrens XH, Dorian P, Backx PH
Curr Opin Cardiol. 2014 Nov 11;
Redpath CJ, Backx PH
J Am Heart Assoc. 2014 Oct;3(5):e001018
Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP, Gramolini AO
Circ Cardiovasc Genet. 2014 Sep 11;
Perrin MJ, Adler A, Green S, Al-Zoughool F, Doroshenko P, Orr N, Uppal S, Healey JS, Birnie D, Sanatani S, Gardner M, Champagne J, Simpson C, Ahmad K, van den Berg MP, Chauhan V, Backx PH, van Tintelen JP, Krahn AD, Gollob MH
J Mol Cell Cardiol. 2014 Oct;75:100-10
Xie L, Liang T, Kang Y, Lin X, Sobbi R, Xie H, Chao C, Backx P, Feng ZP, Shyng SL, Gaisano HY
Methods Mol Biol. 2014;1181:203-14
Liu J, Backx PH
Am J Physiol Cell Physiol. 2014 Jun 15;306(12):C1191-9
Diaz RJ, Harvey K, Boloorchi A, Hossain T, Hinek A, Backx PH, Wilson GJ
J Hypertens. 2014 Jul;32(7):1523-33; discussion 1533
Papageorgiou PC, Chan CT, Yeo EL, Backx PH, Floras JS

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Professor, Departments of Physiology and Medicine, University of Toronto