Peter H Backx, PhD, DVM

Our research interests focus in two main areas: the molecular structure of cardiac ion channels and the physiological role of cardiac ion channels in normal and diseased myocardium.

The ultimate goal of these studies is develop therapeutic agents to treat cardiovascular disease by targeting ion channels. Our recent results in transgenic mice suggest that alterations in cardiac ion channel function can initiate and contribute to heart disease progression.

In another set of studies we have developed a novel paradigm for the creation of tissue-specific agents for the modulation of ion channel function.
J Biol Chem. 2006 Apr 7;281(14):9152-62
Xu J, Gong NL, Bodi I, Aronow BJ, Backx PH, Molkentin JD
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2446-51
Gramolini AO, Trivieri MG, Oudit GY, Kislinger T, Li W, Patel MM, Emili A, Kranias EG, Backx PH, Maclennan DH
Mol Cell Biol. 2005 Dec;25(23):10261-72
Joza N, Oudit GY, Brown D, Bénit P, Kassiri Z, Vahsen N, Benoit L, Patel MM, Nowikovsky K, Vassault A, Backx PH, Wada T, Kroemer G, Rustin P, Penninger JM
Biochem Biophys Res Commun. 2005 Dec 16;338(2):783-92
Hui K, Gardzinski P, Sun HS, Backx PH, Feng ZP
Cell. 2005 Oct 21;123(2):347-58
Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG
Circ Res. 2005 Aug 19;97(4):380-90
Kassiri Z, Oudit GY, Sanchez O, Dawood F, Mohammed FF, Nuttall RK, Edwards DR, Liu PP, Backx PH, Khokha R
Circ Res. 2005 May 27;96(10):1079-86
Kerfant BG, Gidrewicz D, Sun H, Oudit GY, Penninger JM, Backx PH
J Gen Physiol. 2005 May;125(5):493-503
D'Avanzo N, Cho HC, Tolokh I, Pekhletski R, Tolokh I, Gray C, Goldman S, Backx PH
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Feb;71(2 Pt 1):021912
Tolokh IS, Tolokh II, Cho HC, D'Avanzo N, Backx PH, Goldman S, Gray CG
Mol Pharmacol. 2005 Feb;67(2):424-34
Tsang SY, Tsushima RG, Tomaselli GF, Li RA, Backx PH


Professor, Departments of Physiology and Medicine, University of Toronto