Peter H Backx

Peter H Backx, PhD, DVM

Our research interests focus in two main areas: the molecular structure of cardiac ion channels and the physiological role of cardiac ion channels in normal and diseased myocardium.

The ultimate goal of these studies is develop therapeutic agents to treat cardiovascular disease by targeting ion channels. Our recent results in transgenic mice suggest that alterations in cardiac ion channel function can initiate and contribute to heart disease progression.

In another set of studies we have developed a novel paradigm for the creation of tissue-specific agents for the modulation of ion channel function.
Nat Biotechnol. 2016 Sep 12;
Olofsson PS, Steinberg BE, Sobbi R, Cox MA, Ahmed MN, Oswald M, Szekeres F, Hanes WM, Introini A, Liu SF, Holodick NE, Rothstein TL, Lövdahl C, Chavan SS, Yang H, Pavlov VA, Broliden K, Andersson U, Diamond B, Miller EJ, Arner A, Gregersen PK, Backx PH...
Adv Drug Deliv Rev. 2016 Jan 11;
Liu J, Laksman Z, Backx PH
Sci Rep. 2016;6:19197
Kim KH, Rosen A, Hussein SM, Puviindran V, Korogyi AS, Chiarello C, Nagy A, Hui CC, Backx PH
J Biol Chem. 2016 Jan 7;
Panama BK, Korogyi AS, Aschar-Sobbi R, Oh Y, Gray CB, Gang H, Heller Brown J, Kirshenbaum LA, Backx PH
Front Biosci (Schol Ed). 2016;8:143-59
Cordeiro JM, Calloe K, Aschar-Sobbi R, Kim KH, Korogyi A, Occhipinti D, Backx PH, Panama BK
PLoS One. 2015;10(7):e0133274
Liu J, Kim KH, Morales MJ, Heximer SP, Hui CC, Backx PH
J Mol Cell Cardiol. 2015 Jul 18;
Dadson K, Turdi S, Hashemi S, Zhao J, Polidovitch N, Beca S, Backx PH, McDermott JC, Sweeney G
Proc Natl Acad Sci U S A. 2015 Apr 15;
Chung YW, Lagranha C, Chen Y, Sun J, Tong G, Hockman SC, Ahmad F, Esfahani SG, Bae DH, Polidovitch N, Wu J, Rhee DK, Lee BS, Gucek M, Daniels MP, Brantner CA, Backx PH, Murphy E, Manganiello VC
Nat Commun. 2015;6:6018
Aschar-Sobbi R, Izaddoustdar F, Korogyi AS, Wang Q, Farman GP, Yang F, Yang W, Dorian D, Simpson JA, Tuomi JM, Jones DL, Nanthakumar K, Cox B, Wehrens XH, Dorian P, Backx PH

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Professor, Departments of Physiology and Medicine, University of Toronto