Peter H Backx, PhD, DVM

Our research interests focus in two main areas: the molecular structure of cardiac ion channels and the physiological role of cardiac ion channels in normal and diseased myocardium.

The ultimate goal of these studies is develop therapeutic agents to treat cardiovascular disease by targeting ion channels. Our recent results in transgenic mice suggest that alterations in cardiac ion channel function can initiate and contribute to heart disease progression.

In another set of studies we have developed a novel paradigm for the creation of tissue-specific agents for the modulation of ion channel function.
J Mol Cell Cardiol. 2019 Apr 30;132:60-70
Polidovitch N, Yang S, Sun H, Lakin R, Ahmad F, Gao X, Turnbull PC, Chiarello C, Perry CGR, Manganiello V, Yang P, Backx PH
Matrix Biol. 2019 Apr 11;:
Zhao Y, Rafatian N, Wang EY, Feric NT, Lai BFL, Knee-Walden EJ, Backx PH, Radisic M
J Mol Cell Cardiol. 2019 Feb 20;:
Lakin R, Polidovitch N, Yang S, Guzman C, Gao X, Wauchop M, Backx PH
Cell. 2019 Jan 18;:
Zhao Y, Rafatian N, Feric NT, Cox BJ, Aschar-Sobbi R, Wang EY, Aggarwal P, Zhang B, Conant G, Ronaldson-Bouchard K, Pahnke A, Protze S, Lee JH, Davenport Huyer L, Jekic D, Wickeler A, Naguib HE, Keller GM, Vunjak-Novakovic G, Broeckel U, Backx PH,...
J Physiol. 2019 Jan 23;:
Hughes MC, Ramos SV, Turnbull PC, Edgett BA, Huber JS, Polidovitch N, Schlattner U, Backx PH, Simpson JA, Perry CGR
Front Physiol. 2018;9:841
Lakin R, Guzman C, Izaddoustdar F, Polidovitch N, Goodman JM, Backx PH
Appl Physiol Nutr Metab. 2018 May 29;:
Goodman JM, Banks L, Connelly KA, Yan A, Backx PH, Dorian P
PLoS One. 2018;13(5):e0197273
Liu J, Bayer JD, Aschar-Sobbi R, Wauchop M, Spears D, Gollob M, Vigmond EJ, Tsushima R, Backx PH, Chauhan VS
Cardiovasc Res. 2018 Apr 10;:
Barichello S, Roberts JD, Backx P, Boyle P, Laksman Z
Clin Sci (Lond). 2018 Feb 27;:
Sadi AM, Afroze T, Siraj MA, Momen A, White-Dzuro C, Zarrin-Khat D, Handa S, Ban K, Kabir MG, Trivieri MG, Gros R, Backx P, Husain M

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Professor, Departments of Physiology and Medicine, University of Toronto