Patricia A Shaw, MD, FRCPC

Ovarian Cancer
Ovarian and tubal serous tumourigenesis
Characterization of hereditary ovarian/tubal cancers
Gene expression profiling of epithelial ovarian cancer

Serous carcinoma
Serous carcinoma, the most common type of ovarian and tubal carcinoma, usually presents with extra-ovarian disease, and has a high mortality rate. Using hereditary ovarian cancer as a model, we are studying the early molecular/genetic events that lead to malignant transformation. We are also attempting to further classify serous cancer using histological, molecular, and outcome data and gene expression profiling.

With the ultimate goal of more effectively identifying women at risk, and of developing preventative strategies and personalized cancer therapies, we have established the Toronto Ovarian Cancer Research Network (TOCRN), a multi-disciplinary and multi-centre ovarian cancer research network of scientists and oncologists. With translational research a major focus, the Ovarian Tissue Bank and Database, developed in 1996, is a key resource for the majority of ongoing studies within the group.
Am J Pathol. 2018 Feb 16;:
Cybulska P, Stewart JM, Sayad A, Virtanen C, Shaw PA, Clarke B, Stickle N, Bernardini MQ, Neel BG
Nat Commun. 2017 Oct 17;8(1):990
Ducie J, Dao F, Considine M, Olvera N, Shaw PA, Kurman RJ, Shih IM, Soslow RA, Cope L, Levine DA
J Clin Oncol. 2017 Apr 11;:JCO2016703439
Samimi G, Bernardini MQ, Brody LC, Caga-Anan CF, Campbell IG, Chenevix-Trench G, Couch FJ, Dean M, de Hullu JA, Domchek SM, Drapkin R, Spencer Feigelson H, Friedlander M, Gaudet MM, Harmsen MG, Hurley K, James PA, Kwon JS, Lacbawan F, Lheureux S, Mai...
Mol Metab. 2017 Apr;6(4):327-339
Zhang P, Chu T, Dedousis N, Mantell BS, Sipula I, Li L, Bunce KD, Shaw PA, Katz LS, Zhu J, Argmann C, O'Doherty RM, Peters DG, Scott DK
PLoS One. 2017;12(3):e0171882
Chu T, Shaw PA, Yeniterzi S, Dunkel M, Rajkovic A, Hogge WA, Bunce KD, Peters DG
J Clin Oncol. 2017 Feb 21;:JCO2016713677
Lheureux S, Bruce JP, Burnier JV, Karakasis K, Shaw PA, Clarke BA, Yang SY, Quevedo R, Li T, Dowar M, Bowering V, Pugh TJ, Oza AM
Nat Med. 2017 Feb 06;:
Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA, Lang PA, Berman HK, Pugh TJ, Lanier LL, Ohashi PS
PLoS One. 2016;11(9):e0163578
Chu T, Yeniterzi S, Yatsenko SA, Dunkel M, Shaw PA, Bunce KD, Peters DG
Clin Cancer Res. 2016 Sep 6;
Lo CS, Sanii S, Kroeger DR, Milne K, Talhouk A, Chiu DS, Rahimi K, Shaw PA, Clarke BA, Nelson BH
PLoS One. 2016;11(6):e0153182
Chu T, Yeniterzi S, Yatsenko SA, Dunkel M, Shaw PA, Bunce KD, Peters DG