Patricia A Shaw, MD, FRCPC

Ovarian Cancer
Ovarian and tubal serous tumourigenesis
Characterization of hereditary ovarian/tubal cancers
Gene expression profiling of epithelial ovarian cancer

Serous carcinoma
Serous carcinoma, the most common type of ovarian and tubal carcinoma, usually presents with extra-ovarian disease, and has a high mortality rate. Using hereditary ovarian cancer as a model, we are studying the early molecular/genetic events that lead to malignant transformation. We are also attempting to further classify serous cancer using histological, molecular, and outcome data and gene expression profiling.

With the ultimate goal of more effectively identifying women at risk, and of developing preventative strategies and personalized cancer therapies, we have established the Toronto Ovarian Cancer Research Network (TOCRN), a multi-disciplinary and multi-centre ovarian cancer research network of scientists and oncologists. With translational research a major focus, the Ovarian Tissue Bank and Database, developed in 1996, is a key resource for the majority of ongoing studies within the group.
Oncoimmunology. 2019;8(12):e1665460
MacGregor HL, Garcia-Batres C, Sayad A, Elia A, Berman HK, Toker A, Katz SR, Shaw PA, Clarke BA, Crome SQ, Robert-Tissot C, Bernardini MQ, Nguyen LT, Ohashi PS
EBioMedicine. 2019 May 08;:
Sowamber R, Chehade R, Bitar M, Dodds LV, Milea A, Slomovitz B, Shaw PA, George SHL
Platelets. 2019 Feb 13;:1-10
Parker WAE, Orme RC, Hanson J, Stokes HM, Bridge CM, Shaw PA, Sumaya W, Thorneycroft K, Petrucci G, Porro B, Judge HM, Ajjan RA, Rocca B, Storey RF
Genome Med. 2018 Oct 31;10(1):81
Yang SYC, Lheureux S, Karakasis K, Burnier JV, Bruce JP, Clouthier DL, Danesh A, Quevedo R, Dowar M, Hanna Y, Li T, Lu L, Xu W, Clarke BA, Ohashi PS, Shaw PA, Pugh TJ, Oza AM
Genes Chromosomes Cancer. 2018 Aug 24;:
Dickson BC, Lum A, Swanson D, Bernardini MQ, Colgan TJ, Shaw PA, Yip S, Lee CH
Clin Cancer Res. 2018 Aug 14;:
Lheureux S, Tinker AV, Clarke BA, Ghatage P, Welch S, Weberpals JI, Dhani NC, Butler MO, Tonkin K, Tan Q, Tan DSP, Brooks K, Ramsahai J, Wang L, Pham NA, Shaw PA, Tsao MS, Garg S, Stockley TL, Oza AM
Clin Cancer Res. 2018 Jul 31;:
Toker A, Nguyen LT, Stone SC, Yang C, Katz SR, Shaw PA, Clarke BA, Ghazarian DA, Al Habeeb AS, Easson AM, Leong W, McCready D, Reedijk M, Guidos CJ, Pugh TJ, Bernardini MQ, Ohashi PS
Am J Pathol. 2018 Feb 16;:
Cybulska P, Stewart JM, Sayad A, Virtanen C, Shaw PA, Clarke B, Stickle N, Bernardini MQ, Neel BG
Nat Commun. 2017 Oct 17;8(1):990
Ducie J, Dao F, Considine M, Olvera N, Shaw PA, Kurman RJ, Shih IM, Soslow RA, Cope L, Levine DA
J Clin Oncol. 2017 Apr 11;:JCO2016703439
Samimi G, Bernardini MQ, Brody LC, Caga-Anan CF, Campbell IG, Chenevix-Trench G, Couch FJ, Dean M, de Hullu JA, Domchek SM, Drapkin R, Spencer Feigelson H, Friedlander M, Gaudet MM, Harmsen MG, Hurley K, James PA, Kwon JS, Lacbawan F, Lheureux S, Mai...