Michael D Sherar, PhD

Our laboratory is working on the development of image guided minimally invasive therapies (MIT) for cancer treatment, with foci in thermal therapy and ultrasound image guidance. This work is based on the broad hypothesis that image guided MIT's can achieve equivalent or better efficacy and improved complication profiles than standard treatments for some solid tumour sites.

Specifically, we are currently engaged in clinical trials in microwave thermal therapy for prostate cancer, radiofrequency thermal therapy for kidney cancer and the use of high frequency ultrasound imaging to monitor the process of apoptosis as an early surrogate marker for tumour response to radiation or chemotherapy in basal cell carcinoma and other superficial cancers. Earlier, laboratory stage work on the development of a novel, completely non-invasive ultrasound image guided ultrasound thermal therapy system with application to renal cancer is in progress. Another main area of focus is the development of treatment planning systems for MIT's including thermal therapy and photodynamic therapy.

Graduate students are involved in all aspects of the research cycle from, theoretical analysis and modelling, technology development and evaluation to animal and finally human trials.
Healthc Pap. 2018 Apr;17(4):14-26
Marchildon GP, Sherar M
Spine J. 2015 Mar 24;
Pezeshki PS, Davidson S, Akens MK, Murphy K, McCann C, Sherar M, Whyne CM, Yee AJ
Healthc Q. 2013;16(3):27-33
Brierley JD, Srigley JR, Yurcan M, Li B, Rahal R, Ross J, King MJ, Sherar M, Skinner R, Sawka C
J Vasc Interv Radiol. 2012 Nov;23(11):1522-8
Furse A, Miller BJ, McCann C, Kachura JR, Jewett MA, Sherar MD
Phys Med Biol. 2009 Apr 21;54(8):2293-313
Davidson SR, Weersink RA, Haider MA, Gertner MR, Bogaards A, Giewercer D, Scherz A, Sherar MD, Elhilali M, Chin JL, Trachtenberg J, Wilson BC
IEEE Trans Ultrason Ferroelectr Freq Control. 2000;47(6):1363-71
Foster FS, Harasiewicz KA, Sherar MD
IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Nov;54(11):2272-82
Leavens C, Burns PN, Sherar MD
IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Oct;54(10):2082-90
Leavens C, Williams R, Foster FS, Burns PN, Sherar MD