Mary Pat McAndrews, PhD

My primary research interest is the functional organization of memory. I use a number of different techniques to understand which brain networks contribute to different types of memory processes and how these can be disturbed and/or reorganized by focal brain damage.

One research theme in my lab involves studies on the patterns of memory impairments in patients with damage or dysfunction in the medial temporal lobe of the brain. This primarily involves patients with temporal lobe epilepsy, but we also have projects examining patients with mild cognitive impairment and individuals who have received gamma radiation to that area of the brain. We are examining the impact of damage to mesial temporal structures on different forms or aspects of memory (e.g., autobiographical, episodic, semantic, relational memory).

We also use fMRI to examine patterns of neural activation in memory and language in health and disease, and neuroplasticity or functional re-organization associated with chronic neurologic conditions and surgical interventions. More recently, we have begun using electrophysiological techniques to understand memory organization. Specific studies employ electrical recording of neuronal signals in the medial temporal lobe in epilepsy patients, electrical stimulation in those circuits in patients with deep brain stimulation or intracranial electrodes, and surface EEG to map neocortical networks involved in different aspects of memory processing.

In addition to addressing key questions in cognitive neuroscience, our aim is to provide clinically useful information (e.g., better tools for the evaluation of deficits and functional change) that can be applied in epilepsy, neurodegenerative disorders and other conditions with focal brain damage in the temporal lobes. Another long-term goal of the research is to identify individual difference factors contributing to vulnerability or resilience (i.e., cerebral reserve) to disease/disorder; this will enable better therapeutic targeting and prognosis.
 

Crit Care Med. 2006 Jan;34(1):81-6
Cameron JI, Herridge MS, Tansey CM, McAndrews MP, Cheung AM
J Neurosci. 2005 Sep 14;25(37):8402-6
Davis KD, Taylor KS, Hutchison WD, Dostrovsky JO, McAndrews MP, Richter EO, Lozano AM
J Anat. 2005 Jul;207(1):35-66
Moscovitch M, Rosenbaum RS, Gilboa A, Addis DR, Westmacott R, Grady C, McAndrews MP, Levine B, Black S, Winocur G, Nadel L
Hepatology. 2005 Apr;41(4):801-8
McAndrews MP, Farcnik K, Carlen P, Damyanovich A, Mrkonjic M, Jones S, Heathcote EJ
Neuroimage. 2004 Dec;23(4):1460-71
Addis DR, McIntosh AR, Moscovitch M, Crawley AP, McAndrews MP
Hippocampus. 2004;14(6):752-62
Addis DR, Moscovitch M, Crawley AP, McAndrews MP
Brain Cogn. 2002 Jul;49(2):225-8
Mandzia J, Black S, Grady C, McAndrews MP, Graham S
J Neurosurg. 2004 Jul;101(1):43-7
Brodkey JA, Tasker RR, Hamani C, McAndrews MP, Dostrovsky JO, Lozano AM
Can J Neurol Sci. 2004 May;31(2):254-6
Wennberg R, McAndrews MP, Mikulis D

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Professor, Dept. of Psychology, University of Toronto
Professional Practice Leader in Psychology, UHN (PM Cancer Centre, TGH, TWH sites)
Director, Neuropsychology Clinic, Krembil Neuroscience Program, UHN