Liran Shlush

The aging of the human hematopoietic system is typically correlated with: 1) clonal hematopoiesis 2) myeloid malignancies 3) reduced T and B cell clonal diversity 4) reduced myeloid cells function 5) red to yellow marrow transition. Understanding the evolutionary principals driving these phenotypes is the first step in early diagnosis and treatment of hematopoiesis malfunction.

Hematopoiesis failure in humans is a long process of somatic selection. Somatic evolution creates new clones exploring the fitness space. Without changes in the somatic environment new clones will loose to the young hematopoietic system which have been optimized over millions of years of germline evolution. Under changing environment, the fittest clones will gradually take over and in time due to antagonistic pleiotropy will lead to a disease.

Our lab is a multidisciplinary lab composed of hematologists, evolutionary biologists and computationalsystem biologists all trying to understand the rules of human hematopoietic aging.

Eur J Med Genet. 2019 Mar 25;:
Weiss K, Ekhilevitch N, Cohen L, Bratman-Morag S, Bello R, Martinez AF, Hadid Y, Shlush LI, Kurolap A, Paperna T, Mory A, Baris HN, Muenke M
JAMA Cardiol. 2019 Mar 13;:
Calvillo-Argüelles O, Jaiswal S, Shlush LI, Moslehi JJ, Schimmer A, Barac A, Thavendiranathan P
Exp Hematol. 2018 Oct 20;:
Luciani GM, Xie L, Dilworth D, Tierens A, Moskovitz Y, Murison A, Szewczyk MM, Mitchell A, Lupien M, Shlush L, Dick JE, Arrowsmith CH, Barsyte-Lovejoy D, Minden MD
Cell. 2018 Sep 20;175(1):171-185.e25
Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, Shaham M, Rivlin A, Omer I, Zinger A, Elias S, Winter E, Erdman PE, Sullivan RW, Fung L, Mercurio F, Li D, Vacca J, Kaushansky N, Shlush L, Oren M, Levine R, Pikarsky E, Snir-Alkalay I,...
Nature. 2018 Jul 09;:
Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao Z, Cirlan I, Pugh TJ, Soave D, Ng K, Latimer C, Hardy C, Raine K, Jones D, Hoult D, Britten A,...
Blood. 2018 Feb 01;131(5):496-504
Shlush LI
Nature. 2017 07 06;547(7661):104-108
Shlush LI, Mitchell A, Heisler L, Abelson S, Ng SWK, Trotman-Grant A, Medeiros JJF, Rao-Bhatia A, Jaciw-Zurakowsky I, Marke R, McLeod JL, Doedens M, Bader G, Voisin V, Xu C, McPherson JD, Hudson TJ, Wang JCY, Minden MD, Dick JE
Oncotarget. 2017 Mar 07;8(10):16712-16727
Zipin-Roitman A, Aqaqe N, Yassin M, Biechonski S, Amar M, van Delft MF, Gan OI, McDermott SP, Buzina A, Ketela T, Shlush L, Xie S, Voisin V, Moffat J, Minden MD, Dick JE, Milyavsky M
Nature. 2017 02 02;542(7639):124
Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson GW, Connor AA, Denroche RE, Liang SB, Brown AM, Kim JC, Wang T, Simpson JT, Beck T, Borgida A, Buchner N, Chadwick D, Hafezi-Bakhtiari S, Dick JE, Heisler L, Hollingsworth MA, Ibrahimov E, Jang GH, Johns...
Nature. 2016 Oct 20;538(7625):378-382
Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson GW, Connor AA, Denroche RE, Liang SB, Brown AM, Kim JC, Wang T, Simpson JT, Beck T, Borgida A, Buchner N, Chadwick D, Hafezi-Bakhtiari S, Dick JE, Heisler L, Hollingsworth MA, Ibrahimov E, Jang GH, Johns...

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