Jonathan O Dostrovsky

Jonathan O Dostrovsky, PhD

The major interest of our lab is in elucidating the central mechanisms involved in perception of touch, pain and temperature and the pathophysiology of movement disorders.

Most of the studies employ extracellular single unit recordings although some anatomical and psychophysical techniques are also used. Currently most of the projects involve studies on human patients undergoing functional stereotactic surgery for the alleviation of movement disorders or chronic pain. In these studies microelectrode recordings and microstimulation in thalamus, globus pallidus and subthalamic nucleus are performed in awake patients.

The major current studies are examining the
  • Functional characteristics of neurons in motor thalamus, globus pallidus and subthalamic nucleus and the alterations of their responses in various movement disorder sensations
  • Oscillatory activity of neurons and local field potentials in the basal ganglia
  • Mechanisms underlying stimulation produced analgesia
  • Role of thalamus in mediating acute and chronic pain and temperature
  • Mechanisms of sensitization of neurons in rat trigeminal nucleus and thalamus to noxious stimuli
  • Mechanisms of peripheral release of substance P and plasma extravasation

Our lab has strong ties with other researchers at the Krembil Research Institute (Chen, Davis, Hutchison, Lang, Lozano, Moro); and the University of Toronto's Department of Physiology (Charlton) and Dental School (Sessle, Hu).

Related Links

Biol Psychiatry. 2014 Sep 30;
Srejic LR, Prescott IA, Zhang P, Strauss I, Dostrovsky JO, Giacobbe P, Kennedy SH, Lozano AM, Hamani C, Hutchison WD
Cortex. 2014 Nov;60:139-44
Lipsman N, Nakao T, Kanayama N, Krauss JK, Anderson A, Giacobbe P, Hamani C, Hutchison WD, Dostrovsky JO, Womelsdorf T, Lozano AM, Northoff G
Exp Neurol. 2014 Nov;261:782-90
Basha D, Dostrovsky JO, Lopez Rios AL, Hodaie M, Lozano AM, Hutchison WD
Neurobiol Dis. 2014 Nov;71:24-33
Prescott IA, Liu LD, Dostrovsky JO, Hodaie M, Lozano AM, Hutchison WD
PLoS One. 2014;9(5):e96026
Birdno MJ, Tang W, Dostrovsky JO, Hutchison WD, Grill WM
Pain. 2014 Jun;155(6):1168-73
Watson CP, Mackinnon SE, Dostrovsky JO, Bennett GJ, Farran RP, Carlson T
Biol Psychiatry. 2013 Nov 15;74(10):714-9
Laxton AW, Neimat JS, Davis KD, Womelsdorf T, Hutchison WD, Dostrovsky JO, Hamani C, Mayberg HS, Lozano AM
Neurochem Int. 2013 May;62(6):831-5
Kumar N, Cherkas PS, Varathan V, Miyamoto M, Chiang CY, Dostrovsky JO, Sessle BJ, Coderre TJ

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Professor, Department of Physiology, Faculty of Medicine and Faculty of Dentistry