Jonathan M Brotchie, PhD

Parkinson's disease - increasing understanding and defining new therapies

Dr. Brotchie's research is focused on understanding the neural mechanisms underlying movement disorders, in particular Parkinson's disease. His focus is on identifying and understanding interactions between the multiple neurotransmitter systems found within the basal ganglia in:
  • The generation of symptoms of movement disorders
  • The development of side effects of current treatments e.g. L-DOPA-induced dyskinesia.
  • Neurodegeneration in Parkinson's disease
  • Mechanisms compensating for loss of dopamine in pre-symptomatic stages of Parkinson's disease.
The approaches applied span basic molecular biological and pharmacological studies in vitro to studies in animal models, rodent and non-human primate (MPTP), of movement disorders. In addition to increasing knowledge of basal ganglia function in health and disease, this work has helped identify several novel therapeutic approaches to movement disorders, including manipulation of cannabinoid, opioid, glutamatergic and serotonergic systems, which are currently in the process of being translated into therapies. In this latter respect, he enjoys close collaborations with the TWH Movement Disorders Clinic with respect to conducting Phase II clinical trials.
Neuropharmacology. 2018 Jun 01;:
Johnston TH, Lacoste AMB, Visanji NP, Lang AE, Fox SH, Brotchie JM
Acta Neuropathol Commun. 2018 May 10;6(1):39
Henrich MT, Geibl FF, Lee B, Chiu WH, Koprich JB, Brotchie JM, Timmermann L, Decher N, Matschke LA, Oertel WH
Neurobiol Dis. 2018 Mar 20;:
Gleave JA, Arathoon LR, Trinh D, Lizal KE, Giguère N, Barber JEM, Najarali Z, Hassan Khan M, Thiele SL, Semmen MS, Koprich JB, Brotchie JM, Eubanks JH, Trudeau LE, Nash JE
Neuropharmacology. 2017 Nov 29;:
Johnston TH, Versi E, Howson PA, Ravenscroft P, Fox SH, Hill MP, Reidenberg BE, Corey R, Brotchie JM
Ann Neurol. 2017 Oct 06;:
Koprich JB, Brotchie JM, Musacchio T, Volkmann J, Ip CW
Nat Rev Neurosci. 2017 Jul 13;:
Koprich JB, Kalia LV, Brotchie JM
Neurobiol Dis. 2017 Jun 30;:
Arathoon LR, Gleave JA, Trinh D, Lizal KE, Giguère N, Barber JHM, Najarali Z, Hassan Khan M, Thiele SL, Semmen MS, Koprich JB, Brotchie JM, Eubanks JH, Trudeau LE, Nash JE
Ann Neurol. 2017 May 03;:
Musacchio T, Rebenstorff M, Fluri F, Brotchie JM, Volkmann J, Koprich JB, Ip CW