Jonathan M Brotchie

Jonathan M Brotchie, PhD

Parkinson's disease - increasing understanding and defining new therapies

Dr. Brotchie's research is focused on understanding the neural mechanisms underlying movement disorders, in particular Parkinson's disease. His focus is on identifying and understanding interactions between the multiple neurotransmitter systems found within the basal ganglia in:
  • The generation of symptoms of movement disorders
  • The development of side effects of current treatments e.g. L-DOPA-induced dyskinesia.
  • Neurodegeneration in Parkinson's disease
  • Mechanisms compensating for loss of dopamine in pre-symptomatic stages of Parkinson's disease.
The approaches applied span basic molecular biological and pharmacological studies in vitro to studies in animal models, rodent and non-human primate (MPTP), of movement disorders. In addition to increasing knowledge of basal ganglia function in health and disease, this work has helped identify several novel therapeutic approaches to movement disorders, including manipulation of cannabinoid, opioid, glutamatergic and serotonergic systems, which are currently in the process of being translated into therapies. In this latter respect, he enjoys close collaborations with the TWH Movement Disorders Clinic with respect to conducting Phase II clinical trials.
Nat Rev Neurosci. 2017 Jul 13;:
Koprich JB, Kalia LV, Brotchie JM
Neurobiol Dis. 2017 Jun 30;:
Arathoon LR, Gleave JA, Trinh D, Lizal KE, Giguère N, Barber JHM, Najarali Z, Hassan Khan M, Thiele SL, Semmen MS, Koprich JB, Brotchie JM, Eubanks JH, Trudeau LE, Nash JE
Ann Neurol. 2017 May 03;:
Musacchio T, Rebenstorff M, Fluri F, Brotchie JM, Volkmann J, Koprich JB, Ip CW
Trends Neurosci. 2016 Oct 21;:
Visanji NP, Brotchie JM, Kalia LV, Koprich JB, Tandon A, Watts JC, Lang AE
Acta Neuropathol Commun. 2016 Oct 3;4(1):108
Ip CW, Isaias IU, Kusche-Tekin BB, Klein D, Groh J, O'Leary A, Knorr S, Higuchi T, Koprich JB, Brotchie JM, Toyka KV, Reif A, Volkmann J
J Pharmacol Exp Ther. 2016 Jun;357(3):562-9
Huot P, Fox SH, Brotchie JM
Mov Disord. 2015 Aug;30(9):1283-8
Ma Y, Johnston TH, Peng S, Zuo C, Koprich JB, Fox SH, Guan Y, Eidelberg D, Brotchie JM

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