Joel Katz

Joel Katz, PhD

Understanding and Preventing Pain
My research program has two major objectives:  
1. To assess the contribution of peripheral injury to the development of pathological pain states in which the central nervous system plays a prominent role.
2. To design and systematically evaluate means of preventing the state of central neural sensitization that develops after injury and that often marks the transition from time-limited pain to chronic pathological pain.

Together, this research forms the basis of a model I have developed to evaluate the contribution of central nervous system plasticity to acute postoperative pain and hyperalgesia by altering the timing and route of administration of various analgesic agents relative to incision.

Surgery provides a context in which the central neural and primary/visceral afferent contributions of noxious intra-operative stimuli to subsequent pain can be studied in a controlled manner. We are conducting randomized, double-blind, placebo-controlled trials to evaluate a preventive approach to postoperative pain (called pre-emptive analgesia) that involves administering a variety of analgesic agents by different routes before incision. We are evaluating the effects of pre-emptive analgesia on intra-operative stress and immune status, postoperative pain, analgesic requirements and psychosocial functioning.

One series of studies assesses the mechanisms underlying the efficacy of pre-emptive analgesia by evaluating the role of specific agents that act at sites on the N-methyl-D-aspartic acid (NMDA) receptor (e.g., non-competitive NMDA channel blockers such as ketamine and amantadine).

A second related area of research is directed at understanding the mechanisms responsible the transition of acute pain to chronic, pathological pain.

I have approached this issue from two perspectives. One involves evaluating the role of pre-amputation pain in contributing to the central neuroplastic changes that underlie phantom limb pain 'memories'.The second involves following up patients after other major surgical procedures in an attempt to identify early predictors of long-term pain.

Other research interests include gender differences in pain and analgesic use, phantom limb pain and pain measurement.
J Pain Res. 2015;8:695-702
Katz J, Weinrib A, Fashler SR, Katznelzon R, Shah BR, Ladak SS, Jiang J, Li Q, McMillan K, Mina DS, Wentlandt K, McRae K, Tamir D, Lyn S, de Perrot M, Rao V, Grant D, Roche-Nagle G, Cleary SP, Hofer SO, Gilbert R, Wijeysundera D, Ritvo P, Janmohamed T,...
Pain. 2015 Jun;156(6):1171-2
Pagé MG, Romero Escobar EM, Katz J, Clarke H
J Nutr. 2015 Sep 30;
Kozuki N, Katz J, Lee AC, Vogel JP, Silveira MF, Sania A, Stevens GA, Cousens S, Caulfield LE, Christian P, Huybregts L, Roberfroid D, Schmiegelow C, Adair LS, Barros FC, Cowan M, Fawzi W, Kolsteren P, Merialdi M, Mongkolchati A, Saville N, Victora CG,...
Gastroenterology. 2015 Aug 13;
Huang C, Haritunians T, Okou DT, Cutler DJ, Zwick ME, Taylor KD, Datta LW, Maranville JC, Liu Z, Ellis S, Chopra P, Alexander JS, Baldassano RN, Cross RK, Dassopoulos T, Dhere TA, Duerr RH, Hanson JS, Hou JK, Hussain SZ, Isaacs KL, Kachelries KE, Kader...
Can J Psychiatry. 2015 Apr;60(4):160-7
Katz J, Rosenbloom BN, Fashler S
N Engl J Med. 2015 Jun 2;
Lonial S, Dimopoulos M, Palumbo A, White D, Grosicki S, Spicka I, Walter-Croneck A, Moreau P, Mateos MV, Magen H, Belch A, Reece D, Beksac M, Spencer A, Oakervee H, Orlowski RZ, Taniwaki M, Röllig C, Einsele H, Wu KL, Singhal A, San-Miguel J, Matsumoto...
Liver Transpl. 2015 May 19;
Holtzman S, Clarke HA, McCluskey SA, Turcotte K, Grant D, Katz J
Pain Pract. 2015 May 19;
Sutherland AM, Clarke HA, Katz J, Katznelson R
Pain. 2015 Apr 15;
Gewandter JS, Dworkin RH, Turk DC, Farrar JT, Fillingim RB, Gilron I, Markman JD, Oaklander AL, Polydefkis MJ, Raja SN, Robinson JP, Woolf CJ, Ziegler D, Ashburn MA, Burke LB, Cowan P, George SZ, Goli V, Graff OX, Iyengar S, Jay GW, Katz J, Kehlet H,...

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Adjunct Scientist, Toronto Rehabilitation Institute
Professor, Department of Anesthesia, University of Toronto
Associate Member, Department of Psychology, Hospital for Sick Children
Professor and Canada Research Chair in Health Psychology, York University