Joel Katz

https://orcid.org/0000-0002-8686-447X
Understanding and Preventing Pain
My research program has two major objectives:  
1. To assess the contribution of peripheral injury to the development of pathological pain states in which the central nervous system plays a prominent role.
2. To design and systematically evaluate means of preventing the state of central neural sensitization that develops after injury and that often marks the transition from time-limited pain to chronic pathological pain.

Together, this research forms the basis of a model I have developed to evaluate the contribution of central nervous system plasticity to acute postoperative pain and hyperalgesia by altering the timing and route of administration of various analgesic agents relative to incision.

Surgery provides a context in which the central neural and primary/visceral afferent contributions of noxious intra-operative stimuli to subsequent pain can be studied in a controlled manner. We are conducting randomized, double-blind, placebo-controlled trials to evaluate a preventive approach to postoperative pain (called pre-emptive analgesia) that involves administering a variety of analgesic agents by different routes before incision. We are evaluating the effects of pre-emptive analgesia on intra-operative stress and immune status, postoperative pain, analgesic requirements and psychosocial functioning.

One series of studies assesses the mechanisms underlying the efficacy of pre-emptive analgesia by evaluating the role of specific agents that act at sites on the N-methyl-D-aspartic acid (NMDA) receptor (e.g., non-competitive NMDA channel blockers such as ketamine and amantadine).

A second related area of research is directed at understanding the mechanisms responsible the transition of acute pain to chronic, pathological pain.

I have approached this issue from two perspectives. One involves evaluating the role of pre-amputation pain in contributing to the central neuroplastic changes that underlie phantom limb pain 'memories'.The second involves following up patients after other major surgical procedures in an attempt to identify early predictors of long-term pain.

Other research interests include gender differences in pain and analgesic use, phantom limb pain and pain measurement.
PLoS One. 2019;14(5):e0215148
Webster F, Rice K, Katz J, Bhattacharyya O, Dale C, Upshur R
Pain. 2019 Apr 06;:
Noel M, Rosenbloom B, Pavlova M, Campbell F, Isaac L, Pagé MG, Stinson J, Katz J
Circ Cardiovasc Qual Outcomes. 2019 Mar;12(3):e005618
Berg DD, Bohula EA, van Diepen S, Katz JN, Alviar CL, Baird-Zars VM, Barnett CF, Barsness GW, Burke JA, Cremer PC, Cruz J, Daniels LB, DeFilippis AP, Haleem A, Hollenberg SM, Horowitz JM, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Ng J, Orgel...
J Pain. 2019 Mar 05;:
Khan JS, Hodgson N, Choi S, Reid S, Paul JE, Hong NJL, Holloway C, Busse JW, Gilron I, Buckley DN, McGillion M, Clarke H, Katz J, Mackey S, Avram R, Pohl K, Rao-Melacini P, Devereaux PJ
BMJ Open. 2019 Mar 01;9(2):e022995
McGillion MH, Henry S, Busse JW, Ouellette C, Katz J, Choinière M, Lamy A, Whitlock R, Pettit S, Hare J, Gregus K, Brady K, Dvirnik N, Yang SS, Parlow J, Dumerton-Shore D, Gilron I, Buckley DN, Shanthanna H, Carroll SL, Coyte PC, Ebrahim S,...
Psychoneuroendocrinology. 2019 Feb 08;103:316-323
Chopra K, Katz JL, Quilty LC, Matthews S, Ravindran A, Levitan RD
Scand J Pain. 2019 Feb 13;:
Dhanju S, Kennedy SH, Abbey S, Katz J, Weinrib A, Clarke H, Bhat V, Ladha K
Pain Med. 2018 Nov 29;:
Darnall BD, Juurlink D, Kerns RD, Mackey S, Van Dorsten B, Humphreys K, Gonzalez-Sotomayor JA, Furlan A, Gordon AJ, Gordon DB, Hoffman DE, Katz J, Kertesz SG, Satel S, Lawhern RA, Nicholson KM, Polomano RC, Williamson OD, McAnally H, Kao MC, Schug S,...
J Med Internet Res. 2018 Nov 15;20(11):e12001
Rahman QA, Janmohamed T, Pirbaglou M, Clarke H, Ritvo P, Heffernan JM, Katz J
Eur J Pain. 2018 Oct 09;:
Pagé MG, Karanicolas PJ, Cleary S, Wei AC, McHardy P, Ladak SSJ, Ayach N, Sawyer J, McCluskey SA, Srinivas C, Katz J, Coburn N, Hallet J, Law C, Greig P, Clarke H

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Adjunct Scientist, Toronto Rehabilitation Institute
Professor, Department of Anesthesia, University of Toronto
Associate Member, Department of Psychology, Hospital for Sick Children
Professor and Canada Research Chair in Health Psychology, York University