Multiple myeloma (MM) is a tumour resulting from clonal expansion of plasma cells and constitutes 10% of hematological malignancies. Survival times in MM are very heterogeneous amongst subgroups with different genetic profiles. Dr. Chang's research focuses on the following:
- Identification of molecular genetic aberrations in the initiation and progression of MM and contribution to the genetic-based risk stratification of MM
- Preclinical study of novel therapeutic agents in MM
- Evaluation of prognostic relevance of immunophenotyping in acute leukemias and contribution to the diagnosis and prognosis of acute leukemias, particularly with normal karyotype