- Lineage specific differentiation of embryonic stem (ES) cells in culture
- Development of the hematopoietic, vascular, and cardiac lineages from ES cells
- Commitment of ES cells to endoderm-derived lineages
- Growth and differentiation of human embryonic stem cells
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures.
Blood. 2007 Apr 1;109(7):2679-87
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
Nat Biotechnol. 2006 Nov;24(11):1402-11
Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages.
Dev Cell. 2006 Nov;11(5):723-32
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells.
Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16806-11
Apoptosis in human glioblastoma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand.
J Neurosurg. 2006 Jul;105(1):88-95
Endocrinology. 2006 Jun;147(6):3007-15
Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor.
Blood. 2006 Apr 15;107(8):3122-30
Blood. 2006 Feb 15;107(4):1357-65
Neurosurg Focus. 2005 Sep 15;19(3):E6
Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation.
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13170-5
Senior Scientist, Princess Margaret Cancer Centre
Director, McEwen Centre for Regenerative Medicine, University Health Network
Lead Scientist, Centre for Commercialization of Regenerative Medicine
Professor, Department of Medical Biophysics, University of Toronto