- Lineage specific differentiation of embryonic stem (ES) cells in culture
- Development of the hematopoietic, vascular, and cardiac lineages from ES cells
- Commitment of ES cells to endoderm-derived lineages
- Growth and differentiation of human embryonic stem cells
Nature. 2008 May 22;453(7194):524-8
Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood.
Cell Stem Cell. 2008 Jan 10;2(1):60-71
Nat Biotechnol. 2007 Dec;25(12):1477-82
Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development.
Trends Cardiovasc Med. 2007 Oct;17(7):240-6
Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo.
J Am Soc Nephrol. 2007 Jun;18(6):1709-20
Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on temozolomide-resistant glioma cells.
J Neurosurg. 2007 Apr;106(4):646-51
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures.
Blood. 2007 Apr 1;109(7):2679-87
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
Nat Biotechnol. 2006 Nov;24(11):1402-11
Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages.
Dev Cell. 2006 Nov;11(5):723-32
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells.
Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16806-11
Senior Scientist, Princess Margaret Cancer Centre
Director, McEwen Centre for Regenerative Medicine, University Health Network
Lead Scientist, Centre for Commercialization of Regenerative Medicine
Professor, Department of Medical Biophysics, University of Toronto