- Lineage specific differentiation of embryonic stem (ES) cells in culture
- Development of the hematopoietic, vascular, and cardiac lineages from ES cells
- Commitment of ES cells to endoderm-derived lineages
- Growth and differentiation of human embryonic stem cells
Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population.
PLoS One. 2011;6(9):e24058
Nat Cell Biol. 2011 Sep;13(9):1092-9
An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling.
Stem Cells. 2011 Feb;29(2):217-28
Nat Biotechnol. 2011 Mar;29(3):267-72
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.
Cell Stem Cell. 2011 Feb 4;8(2):228-40
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.
Development. 2011 Mar;138(5):861-71
Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells.
Development. 2010 Sep 1;137(17):2829-39
Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.
Stem Cells. 2010 Mar 31;28(3):620-32
Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells.
Blood. 2010 Apr 8;115(14):2769-76
The homeobox gene Hex regulates hepatocyte differentiation from embryonic stem cell-derived endoderm.
Hepatology. 2010 Feb;51(2):633-41
Senior Scientist, Princess Margaret Cancer Centre
Director, McEwen Centre for Regenerative Medicine, University Health Network
Lead Scientist, Centre for Commercialization of Regenerative Medicine
Professor, Department of Medical Biophysics, University of Toronto