Edward C Keystone

Edward C Keystone, MD, FRCPC

  • Rheumatoid Arthritis
    Rheumatoid arthritis (RA) is an autoimmune disorder of unknown etiology characterized by cellular/humoral hyperreactivity in a genetically susceptible host. The precise pathogenetic mechanisms which perpetuate chronic inflammation within the joint, remains unknown.
  • Osteoarthritis
    Osteoarthritis is a mild inflammatory disorder of unknown origin. A subset of patients have an inflammatory form of arthritis leading to more Rapid destructive disease. The mechanisms accounting for this subset of OA are unclear.

    Our research efforts are focused towards an understanding of the cellular/molecular events contributing to both the early and late phases of RA as well as the inflammatory subset of OA. We are pursuing several lines of investigation in relation to these goals.
  • Immunologic Effect of Biologic Agents in the Treatment of RA
    We are examining the efficacy and biologic effects of targeted immunobiologic therapies in patients with resistant RA.
  • Angiogenic Factors in the Pathogenesis of RA & OA
    We are examining the role of angiogenic factors (and endogenous inhibitors)in patients with RA.
  • Mechanism of Synoviocyte Survival in RA & OA - Implications for Novel Therapeutic Strategies
    We are delineating the inflammatory pathways contributing to the survivial and growth of synovial lining cells in rheumatoid arthritis.
RMD Open. 2017;3(2):e000445
Keystone EC, Breedveld FC, van der Heijde D, van Vollenhoven RF, Emery P, Smolen JS, Sainsbury I, Florentinus S, Kupper H, Chen K, Kavanaugh A
J Rheumatol. 2017 Aug 15;:
Keystone EC, Genovese MC, Schlichting DE, de la Torre I, Beattie SD, Rooney TP, Taylor PC
Ann Rheum Dis. 2017 Aug 10;:
Keystone EC, Taylor PC, Tanaka Y, Gaich C, DeLozier AM, Dudek A, Zamora JV, Cobos JAC, Rooney T, Bono S, Arora V, Linetzky B, Weinblatt ME
Arthritis Rheumatol. 2017 Jul 10;:
Sharma R, Harris VM, Cavett J, Kurien BT, Liu K, Koelsch KA, Fayaaz A, Chaudhari KS, Radfar L, Lewis D, Stone DU, Kaufman CE, Li S, Segal B, Wallace DJ, Weisman MH, Venuturupalli S, Kelly JA, Pons-Estel B, Jonsson R, Lu X, Gottenberg JE, Anaya JM,...
Ann Intern Med. 2017 May 30;:
Bansback N, Phibbs CS, Sun H, O'Dell JR, Brophy M, Keystone EC, Leatherman S, Mikuls TR, Anis AH, CSP 551 RACAT Investigators
Rheumatology (Oxford). 2017 Mar 08;:
Kavanaugh A, Keystone E, Greenberg JD, Reed GW, Griffith JM, Friedman AW, Saunders KC, Ganguli A
Clin Exp Rheumatol. 2017 Mar 23;
Kuriya B, Schieir O, Lin D, Xiong J, Pope J, Boire G, Haraoui B, Thorne JC, Tin D, Hitchon C, Jamal S, Keystone E, Bykerk VP, CATCH Investigators
Ther Adv Musculoskelet Dis. 2017 Feb;9(2):37-44
Kuriya B, Cohen MD, Keystone E
N Engl J Med. 2017 02 16;376(7):652-662
Taylor PC, Keystone EC, van der Heijde D, Weinblatt ME, Del Carmen Morales L, Reyes Gonzaga J, Yakushin S, Ishii T, Emoto K, Beattie S, Arora V, Gaich C, Rooney T, Schlichting D, Macias WL, de Bono S, Tanaka Y
Rheumatology (Oxford). 2017 Jan 09;:
Barra LJ, Pope JE, Hitchon C, Boire G, Schieir O, Lin D, Thorne CJ, Tin D, Keystone EC, Haraoui B, Jamal S, Bykerk VP, CATCH group


Professor, Department of Immunology, University of Toronto