Edward C Keystone, MD, FRCPC

  • Rheumatoid Arthritis
    Rheumatoid arthritis (RA) is an autoimmune disorder of unknown etiology characterized by cellular/humoral hyperreactivity in a genetically susceptible host. The precise pathogenetic mechanisms which perpetuate chronic inflammation within the joint, remains unknown.
  • Osteoarthritis
    Osteoarthritis is a mild inflammatory disorder of unknown origin. A subset of patients have an inflammatory form of arthritis leading to more Rapid destructive disease. The mechanisms accounting for this subset of OA are unclear.

    Our research efforts are focused towards an understanding of the cellular/molecular events contributing to both the early and late phases of RA as well as the inflammatory subset of OA. We are pursuing several lines of investigation in relation to these goals.
  • Immunologic Effect of Biologic Agents in the Treatment of RA
    We are examining the efficacy and biologic effects of targeted immunobiologic therapies in patients with resistant RA.
  • Angiogenic Factors in the Pathogenesis of RA & OA
    We are examining the role of angiogenic factors (and endogenous inhibitors)in patients with RA.
  • Mechanism of Synoviocyte Survival in RA & OA - Implications for Novel Therapeutic Strategies
    We are delineating the inflammatory pathways contributing to the survivial and growth of synovial lining cells in rheumatoid arthritis.
RMD Open. 2018;4(2):e000738
Pope JE, Movahedi M, Rampakakis E, Cesta A, Sampalis JS, Keystone E, Thorne C, Bombardier C
Semin Arthritis Rheum. 2018 Jul 19;:
Kivitz AJ, Cohen S, Keystone E, van Vollenhoven RF, Haraoui B, Kaine J, Fan H, Connell CA, Bananis E, Takiya L, Fleischmann R
Arthritis Care Res (Hoboken). 2018 Apr 26;:
Van Vollenhoven RF, Lee EB, Fallon L, Zwillich SH, Wilkinson B, Chapman D, Demasi R, Keystone E
Arthritis Care Res (Hoboken). 2018 Feb 16;:
Barber CEH, Schieir O, Lacaille D, Marshall DA, Barnabe C, Hazlewood G, Thorne C, Ahluwalia V, Bartlett SJ, Boire G, Haraoui B, Hitchon CA, Keystone E, Tin D, Pope J, Denning L, Bykerk V, CATCH Investigators
Ann Rheum Dis. 2018 Jan 17;:
van Vollenhoven RF, Keystone EC, Strand V, Pacheco-Tena C, Vencovský J, Behrens F, Racewicz A, Zipp D, Rharbaoui F, Wolter R, Knierim L, Schmeidl R, Zhou X, Aigner S, Dälken B, Wartenberg-Demand A, TREAT2b study team
J Rheumatol. 2018 Jan 15;:
Omair MA, Akhavan P, Naraghi A, Mittoo S, Xiong J, Weber D, Lin D, Weber M, Keystone EC
Clin Immunol. 2017 Nov 28;:
Harris VM, Sharma R, Cavett J, Kurien BT, Liu K, Koelsch KA, Rasmussen A, Radfar L, Lewis D, Stone DU, Erick Kaufman C, Li S, Segal B, Wallace DJ, Weisman MH, Venuturupalli S, Kelly JA, Alarcon-Riquelme ME, Pons-Estel B, Jonsson R, Lu X, Gottenberg JE,...
Arthritis Care Res (Hoboken). 2017 Nov 30;:
Schulman E, Bartlett SJ, Schieir O, Andersen KM, Boire G, Pope JE, Hitchon C, Jamal S, Thorne CJ, Tin D, Keystone EC, Haraoui B, Goodman SM, Bykerk VP, Investigators C
Arthritis Care Res (Hoboken). 2017 Nov 10;:
Nagaraj S, Barnabe C, Schieir O, Pope J, Bartlett SJ, Boire G, Keystone E, Tin D, Haraoui B, Thorne JC, Bykerk VP, Hitchon C, Canadian Early Arthritis Cohort (CATCH) Investigators

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Professor, Department of Immunology, University of Toronto