Donald R Branch, PhD

Dr. Branch's current interests can be broken down into 6 main areas:

  • Signalling involving tyrosine kinases
  • Signalling in HIV/AIDS pathogenesis and disease resistance
  • Mechanism of intravenous immunoglobulin (IVIG) effect in autoimmune inflammatory diseases
  • Replacement of high-dose IVIg in autoimmune/inflammatory diseases
  • Mechanism(s) of action of recombinant Fc multimers to ameliorate rheumatoid arthritis in a mouse model
  • Studies using monocytes and M1/M2 macrophages to understand red blood cell destruction in diseases involving eyrptosis and hyperhemolysis

Current projects include:

  • The function of Ableson tyrosine kinases in HIV infection
  • The function of spleen tyrosine kinase (Syk)-family in HIV infection
  • The role of signalling through the VPAC family of neuroendocrine receptors on HIV infection and resistance to infection
  • Identification of novel treatment modalities for HIV/AIDS
  • The mechanism of IVIG and recombinant Fc multimer treatment for amelioration of autoimmune inflammatory diseases
  • Drug discovery for small molecular weight molecules that inhibit phagocytosis
  • Use of in vitro phagocytosis assays to aid in predicting probability of hemolysis in patients requiring blood transfusion
J Acquir Immune Defic Syndr. 2019 Dec 01;82(4):407-415
McCarthy SDS, Leontyev D, Nicoletti P, Binnington B, Kozlowski HN, Ostrowski M, Cochrane A, Branch DR, Wong RW
Transfusion. 2019 May;59(5):1882-1883
Yung GP, Seebach JD, Baerenzung N, Pendergrast J, Cserti-Gazdewich C, Branch DR
Transfusion. 2019 Mar 30;:
Cote J, Cen S, Fennell K, Pambrun C, Branch DR, Ochoa-Garay G
Transfusion. 2019 Feb;59(2):437-440
Branch DR
Transfusion. 2018 Oct 09;:
Lemay AS, Tong TN, Branch DR, Huang M, Sumner C, Oldfield L, Hawes J, Cserti-Gazdewich CM, Lau W
Transfus Med Rev. 2018 Aug 08;:
Tong TN, Cen S, Branch DR
Blood. 2018 May 24;:
Xu M, Li J, Neves MAD, Zhu G, Carrim N, Yu R, Gupta S, Marshall J, Rotstein O, Peng J, Hou M, Kunishima S, Ware J, Branch DR, Lazarus A, Ruggeri ZM, Freedman J, Ni H
Transfusion. 2018 May 09;:
Kipkeu BJ, Shyian ML, da Silveira Cavalcante L, Duong TT, Yeung RSM, Binnington B, Branch DR, Acker JP, Holovati JL
Clin Exp Immunol. 2018 Apr 28;:
Lewis BJB, Leontyev D, Neschadim A, Blacquiere M, Branch DR



Professor, Department of Medicine and Department of Laboratory Medicine and Pathobiology, University of Toronto
Scientist, Centre for Innovation, Canadian Blood Services