David A Jaffray, PhD

Image-guided radiation therapy

Radiation therapy, a proven cancer treatment, is employed to treat fifty percent of all cancer patients. Recent advances in the techniques of radiation delivery have highlighted the advantages of increasing the precision with which the radiotherapeutic dose distribution can be applied within the body.

The vast majority of work in Dr. Jaffray's laboratory focuses on the development of novel imaging systems and concepts to improve the precision of therapy by generating images at the time of therapy for the purpose of guiding the treatment delivery.

Recent developments have included the construction of megavoltage and kilovoltage imaging systems based upon high-performance charged coupled device cameras, prototyping and evaluation of amorphous-silicon based large-area detectors for megavoltage work. In addition, a kilovoltage cone-beam computed tomography (CT) system has been developed.

These systems have been integrated with the megavoltage treatment devices to improve the precision with which the therapy could be executed without the interference of mechanical immobilization systems. The cone-beam CT approach has also been extended to a mobile C-arm for intra-operative imaging and therapy guidance.

A direct by-product of these investigations is the development of clinical processes that can use the images generated by these systems in a sensible and robust fashion. The development of such image-guidance processes is an active area of ongoing research in the program.

This area has been broadened through the use of cinematographic magnetic resonance imaging (MR) sequences that permit the spatial instabilities that are inherent in the human body to be assessed. These assessments describe a lower limit on the precision with which non-invasive therapy can be applied and they must be considered in the development of robust treatment regimens.

Areas of investigation and development:
  • Physics of x-ray imaging systems: cone-beam CT; x-ray scatter; innovative imaging geometries
  • Contrast agents for image-guided therapy
  • Advanced processes for image-guided procedures
  • Integration of functional imaging data into the radiation therapy process
Eur J Radiol. 2018 Sep;106:192-198
Coolens C, Mohseni H, Dhodi S, Ma S, Keller H, Jaffray DA
ACS Nano. 2018 Jul 13;:
Stapleton S, Dunne M, Milosevic M, Tran CW, Gold MJ, Vedadi A, McKee T, Ohashi PS, Allen C, Jaffray DA
J Natl Cancer Inst. 2017 Jul 01;109(7):
Welch ML, Jaffray DA
Int J Radiat Oncol Biol Phys. 2018 Jun 29;:
Press RH, Shu HG, Shim H, Mountz JM, Kurland BF, Wahl RL, Jones EF, Hylton NM, Gerstner ER, Nordstrom RJ, Henderson L, Kurdziel KA, Vikram B, Jacobs MA, Holdhoff M, Taylor E, Jaffray DA, Schwartz LH, Mankoff DA, Kinahan PE, Linden HM, Lambin P, Dilling...
Radiother Oncol. 2018 Jun 16;:
Pistenmaa DA, Dosanjh M, Amaldi U, Jaffray D, Zubizarreta E, Holt K, Lievens Y, Pipman Y, Coleman CN, Workshop Participants
J Bone Joint Surg Am. 2018 May 16;100(10):e67
Sternheim A, Kashigar A, Daly M, Chan H, Qiu J, Weersink R, Jaffray D, Irish JC, Ferguson PC, Wunder JS
Phys Med Biol. 2018 May 15;:
Stewart JMP, Stapleton S, Chaudary N, Lindsay PE, Jaffray DA
Int J Radiat Oncol Biol Phys. 2018 Jun 01;101(2):292-298
Jaffray DA, Das S, Jacobs PM, Jeraj R, Lambin P

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Professor, Department of Medical Biophysics, University of Toronto
Vice Chair & Professor, Department of Radiation Oncology, University of Toronto
Fidani Chair in Radiation Therapy Physics