David J Kelvin

David J Kelvin, PhD


Senior Scientist, Division of Experimental Therapeutics - Infection & Immunity, Toronto General Hospital Research Institute (TGHRI)
Dr. Kelvin is a Senior Scientist in the Division of Experimental Therapeutics at UHN's Toronto General Hospital Research Institute. He is also the Director of the Division of Immunology at the International Institute of Infection and Immunity in Shantou, China, an internationally-based collaboration between UHN, Shantou Medical College, Shantou University and the University of Hong Kong.

With nearly 22 years of experience in the study of inflammation, functional genomics and host immune responses to viral diseases, Dr. Kelvin is both a pioneer and world leader in the fields of chemokine receptor regulation, inflammatory host responses and regulation of host immunity to severe viral infections. Dr. Kelvin has received several distinguished awards as an investigator, including the Premier's Research Excellence Award and career development awards from the Medical Research Council of Canada.
Previously Dr. Kelvin's lab has focused on various areas of immunity such as transplant rejection, immune cell signaling and chemokine receptor evolution. Dr. Kelvins group comprised the heart of several large network projects involving national and international scientists and clinicians, including TransNet (a CIHR Institute of Infection and Immunity Health Research Program of Excellence), S2K (a Genome Canada-sponsored genomics and proteomics consortium) and the Canadian Network for Vaccines and Immunotherapeutics (a Canadian Networks of Centres of Excellence).

Dr. Kelvin now leads a multidisciplinary immunogenomics team at UHN and Shantou Medical College that currently focuses on host immunity of emerging and established infectious diseases including SARS, avian influenza (H5N1), West Nile Virus, HIV and pandemic and seasonal influenza. Using high throughput sequencing and gene expression profiling techniques, Dr. Kelvin's group has identified key immune mediators that regulate severe infection. As well, the group has outlined distinctive profiles of the host immune response during the onset and evolution of these infections, in particular focusing on defining the chemokine and cytokine networks that are induced during severe courses of illness. As such, the work of Dr. Kelvin's lab has identified novel biomarkers leading to advances in the identification, diagnosis, treatment and vaccination of emerging and established infectious diseases.

Dr. Kelvin's publication record reflects the high productivity of his group with over 135 publications published, many of which are in top tier journals such as Nature Medicine, Nature Immunology and Science. Dr. Kelvin's group is currently developing therapeutics for managing acute respiratory distress syndrome (ARDS)-like disease caused by viral infections.

Transnet

Related Links

PLoS One. 2017;12(2):e0171936
Dong W, Farooqui A, Leon AJ, Kelvin DJ
N Engl J Med. 2016 Sep 8;375(10):e23
Kelvin DJ, Leon AJ, Farooqui A, Liu W
Appl Immunohistochem Mol Morphol. 2016 Jun 2;
Chessa D, Delaconi P, Kelvin N, Campus F, Sanna L, Demurtas MA, Kelvin D, Rubino S, Mazzarello V
N Engl J Med. 2016 Feb 11;374(6):596-8
Farooqui A, Liu W, Kelvin DJ, H7N9 Shantou Working Group, Zeng T, Liu Y, Zhang L, Khan A, Wu X, Wu R, Wu S, Huang L, Cai Y, Kelvin AA, Paquette SG, Hu K, Zheng N, Chen H, Xu S, Lin C, Sun P, Yao Z, Wang J, Ma H, Zhu Z, Lin P, Chen W, Fang X, Bermejo...
J Infect. 2016 May;72(5):525-36
Bermejo-Martin JF, Andaluz-Ojeda D, Almansa R, Gandía F, Gómez-Herreras JI, Gomez-Sanchez E, Heredia-Rodríguez M, Eiros JM, Kelvin DJ, Tamayo E
Sci Rep. 2015;5:17809
Zhang Z, Huang T, Yu F, Liu X, Zhao C, Chen X, Kelvin DJ, Gu J
PLoS Pathog. 2015 Oct;11(10):e1005173
Paquette SG, Banner D, Huang SS, Almansa R, Leon A, Xu L, Bartoszko J, Kelvin DJ, Kelvin AA
Antimicrob Agents Chemother. 2015 Dec;59(12):7255-64
Farooqui A, Huang L, Wu S, Cai Y, Su M, Lin P, Chen W, Fang X, Zhang L, Liu Y, Zeng T, Paquette SG, Khan A, Kelvin AA, Kelvin DJ
J Infect Dev Ctries. 2015 Jun;9(6):543-6
Khan A, Farooqui A, Guan Y, Kelvin DJ
BMC Infect Dis. 2015;15:109
Farooqui A, Leon AJ, Huang L, Wu S, Cai Y, Lin P, Chen W, Fang X, Zeng T, Liu Y, Zhang L, Su T, Chen W, Ghedin E, Zhu H, Guan Y, Kelvin DJ

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Associate Professor, Department of Immunology, University of Toronto
Director, University Health Network Vaccine and Influenza Research and Development Center
Director, Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College (China)