David Hogg

David Hogg, MD, FRCPC

Cancer genetics: melanoma and testicular cancer

The primary focus of my laboratory is cancer genetics. In collaboration with Norman Lassam (who tragically died in August, 2000) my laboratory described one of the first families with a germline mutation in the CDKN2A gene (Liu et al., Oncogene, 11: 405-412, 1995).

We went on to establish a program in inherited melanoma. The overall aim of the Toronto melanoma clinic is to utilize progress in cancer genetic research to focus preventative efforts on a population at high risk for this disease. We hypothesize that such directed surveillance will decrease morbidity and mortality from melanoma in the families and individuals under our care.

The Toronto melanoma program now comprises a clinic to identify and counsel families at risk; a clinical genetic laboratory dedicated to CDKN2A mutation testing; and a basic science program to characterize other genes that predispose to melanoma.

The clinic's multidisciplinary staff includes oncologists, dermatologists, nursing staff, plastic surgeons, a medical geneticist and social workers. Over the past four years, we have accrued over 200 melanoma families and have screened 170 of these kindreds for CDKN2A mutations (Liu et al., Nat Genet, 21: 128-132, 1999). We have also determined that a significant number of patients with multiple primary melanomas carry such mutations (Monzon et al., New Engl J Med, 338: 879-887, 1998).

My second major area of interest is the genetic basis of inherited and sporadic testicular germ cell cancer (Peng et al., Cancer Res, 55: 2871-2875, 1995; King et al., Cancer Res, 57: 209-214, 1997). I am also a member of the International Testicular Cancer Mapping Consortium. We recently published the first description of a testicular cancer susceptibility gene mapping to chromosome Xq27 (Rapley et al., Nat Genet, 24:197-200, 2000).
Am J Kidney Dis. 2017 Jun 22;:
Kitchlu A, Fingrut W, Avila-Casado C, Chan CT, Crump M, Hogg D, Reich HN
Lancet Oncol. 2017 Jun 02;:
Davies MA, Saiag P, Robert C, Grob JJ, Flaherty KT, Arance A, Chiarion-Sileni V, Thomas L, Lesimple T, Mortier L, Moschos SJ, Hogg D, Márquez-Rodas I, Del Vecchio M, Lebbé C, Meyer N, Zhang Y, Huang Y, Mookerjee B, Long GV
Lancet Oncol. 2017 Mar 08;:
Dummer R, Schadendorf D, Ascierto PA, Arance A, Dutriaux C, Di Giacomo AM, Rutkowski P, Del Vecchio M, Gutzmer R, Mandala M, Thomas L, Demidov L, Garbe C, Hogg D, Liszkay G, Queirolo P, Wasserman E, Ford J, Weill M, Sirulnik LA, Jehl V, Bozón V, Long...
Cancer Med. 2016 Sep 29;
Khoja L, Atenafu EG, Templeton A, Qye Y, Chappell MA, Saibil S, Hogg D, Butler MO, Joshua AM
Oncol Lett. 2016 Feb;11(2):1581-1585
Khoja L, Atenafu EG, Ye Q, Gedye C, Chappell M, Hogg D, Butler MO, Joshua AM
Cancer Immunol Res. 2016 Jan 28;
Khoja L, Maurice C, Chappell M, MacMillan L, Al-Habeeb AS, Al-Faraidy N, Butler MO, Rogalla P, Mason W, Joshua AM, Hogg D
Cancer Immunol Res. 2015 Sep 29;
Maurice C, Schneider R, Kiehl TR, Bavi PP, Roehrl MH, Mason WP, Hogg D
Curr Oncol. 2015 Aug;22(4):e320-2
Khoja L, Butler MO, Chappell MA, Hogg D, Joshua AM
Melanoma Res. 2015 Jun 5;
Joshua AM, Monzon JG, Mihalcioiu C, Hogg D, Smylie M, Cheng T



Associate Professor, Department of Medical Biophysics, University of Toronto