Danielle Molinari Andrade

Danielle Molinari Andrade, MD, MSc, FRCPC

Dr. Andrade is the Medical Director of the Epilepsy Program at that University Health Network, University of Toronto. She is the founder and Director of Krembil Neuroscience Epilepsy Genetics Program. Dr. Andrade is also the Director of the Epilepsy Transition Program, a program in collaboration with The Hospital for Sick Children that helps promote coordinated, smooth and efficient transition from the pediatric to the adult health systems for patients with intractable epilepsy. She was the chair of the epilepsy implementation task force sub-group for the development of Guidelines for Transition in Epilepsy for the Province of Ontario. 
 
Dr. Andrade graduated in Medicine from Universidade Federal do Parana (Brazil) and completed her Neurology Residency at Hospital N.S. Gracas (Brazil). She then completed a Master of Sciences at The Hospital for Sick Children, University of Toronto, which was focused on “Protein Therapy for Unverricht-Lundborg Progressive Myoclonus Epilepsy”. Between 2004 and 2006 Dr. Andrade completed an Epilepsy and Clinical Electrophysiology Fellowship at Toronto Western Hospital, University of Toronto.
 
Dr. Andrade’s research interests are in the field of genetic epilepsies and their long-term outcome. Her team identified the first gene associated with SUDEP (sudden, unexpected death in epilepsy) in patients with non-syndromic epilepsy. Her team also discovered the genes responsible for different epilepsies, including Lennox-Gastaut syndrome, Jeavon’s syndrome, teenage-onset neuronal ceroid lipofuccinosis and progressive myoclonus epilepsy. 
 
Dr. Andrade leads UHN's adult Dravet Syndrome program. Along with her collaborators, she has determined that the majority of adults with Dravet syndrome develop early onset parkinsonian features. Her work in this area is now focused on examining the long-term outcome of seizures in Dravet patients treated with deep brain stimulation. 
 
Dr. Andrade’s work on genotype/phenotype correlations in adults with genetic epilepsies has shown that patients with 22q11.2 have an overall lower seizure threshold, even in the absence of genetic generalized epilepsy or structural epilepsy. Her research has also shown that more than 15% of adults with pediatric-onset epilepsy and intellectual disability have a pathogenic copy number variation in their genomes.
 
Dr. Andrade continues to collaborate on national and international initiatives to discover new genes that are associated with common and rare epilepsies, and to identify how these genes affect patient responses to therapy.

 

Epilepsy Behav. 2017 Feb 27;:
Nabbout R, Andrade DM, Bahi-Buisson N, Cross H, Desquerre I, Dulac O, Granata T, Hirsch E, Navarro V, Ouss L, Pearl PL, Schmidt D, Thiele E, Camfield PR, Camfield CS
Epileptic Disord. 2016 Jun 01;18(2):216
Nascimento, Aljaafari D, Rahim M, Krings T, Andrade D
Epilepsy Behav. 2017 Feb 07;:
Nabbout R, Camfield CS, Andrade DM, Arzimanoglou A, Chiron C, Cramer JA, French JA, Kossoff E, Mula M, Camfield PR
Neurol Genet. 2016 Aug;2(4):e83
Nascimento FA, Canafoglia L, Aljaafari D, Muona M, Lehesjoki AE, Berkovic SF, Franceschetti S, Andrade DM
Epilepsy Behav. 2016 Aug;61:180-4
Wissel BD, Dwivedi AK, Gaston TE, Rodriguez-Porcel FJ, Aljaafari D, Hopp JL, Krumholz A, van der Salm SM, Andrade DM, Borlot F, Moseley BD, Cavitt JL, Williams S, Stone J, LaFrance WC, Szaflarski JP, Espay AJ
Eur J Paediatr Neurol. 2016 Jul;20(4):684-5
Borlot F, Andrade DM
Neurol Genet. 2015 Dec;1(4):e28
Nascimento FA, Borlot F, Cossette P, Minassian BA, Andrade DM
Neurosurgery. 2016 Jun;78(6):802-11
Krishna V, King NK, Sammartino F, Strauss I, Andrade DM, Wennberg RA, Lozano AM

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Medical Director, Epilepsy Program, UHN
Krembil Neuroscience Director of Epilepsy Genetics Research Program, UHN
Director,  Epilepsy Transition Program, UHN
Associate Professor, Neurology, University of Toronto