Our laboratory is interested in the cellular mechanisms that result in the proper formation of a specialized membrane domain within muscle, termed the sarcoplasmic reticulum. The sarcoplasmic reticulum is an internal membrane system in muscle that regulates calcium uptake and release in excitation-contraction. We employ a range of current molecular and cellular approaches, as well as advanced proteomic and genomic methods, to investigate the physiology and biochemistry of several key Ca2+ regulatory proteins in cardiac and skeletal muscle.
In particular, we are interested in:
- The factors that regulate Ca2+ release and uptake in the sarcoplasmic reticulum
- The cellular consequences of dysregulation of Ca2+ uptake