We work on novel surgical approaches to treat Parkinson's disease, depression and Alzheimer's disease. We use brain imaging, electrophysiology and surgical techniques. The work in humans is complemented by laboratory work involving cell death in Parkinson's disease, effects of stimulation on hippocampal neurogenesis and animal models of deep brain stimulation.
Mov Disord. 2011 Dec;26(14):2469-70
J Neurosurg Pediatr. 2011 Dec;8(6):565; discussion 565
A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression.
J Neurosurg. 2012 Feb;116(2):315-22
J Neurosurg. 2011 Dec;115(6):1256; discussion 1256-7
J Neurosci. 2011 Sep 21;31(38):13469-84
Int Rev Neurobiol. 2011;98:151-71
Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone.
Exp Neurol. 2011 Nov;232(1):100-4
J Neurosurg. 2012 Jan;116(1):82-3; discussion 83
Prog Brain Res. 2011;194:83-95
Oscillatory activity in the globus pallidus internus: comparison between Parkinson's disease and dystonia.
Clin Neurophysiol. 2012 Feb;123(2):358-68
Senior Scientist, Krembil Research Institute (Krembil)
Affiliated Faculty, Techna Institute for the Advancement of Technology for Health (Techna)
Dan Family Chair in Neurosurgery, University of Toronto
R.R. Tasker Chair in Stereotactic and Functional Neurosurgery
Tier 1 Canada Research Chair in Neuroscience
Professor, Department of Surgery, University of Toronto
University Professor, University of Toronto