Catia Ferreira

Specific Targeting of therapeutic cargos at ovarian cancer cells

Jean Gariepy

Partial

$20,000

Amy Finch

Prophylactic Salpingo-oophorectomy in Women that Carry a BRCA1 or BRCA2 Mutation

S. Narod

Partial

$13,000

(only partial payment made as Amy won another award)

Taymaa May

Characterization of Micropapillary Serous Carcinoma & Low Grade Serous Carcinoma of the Ovary and their precursors

P. Shaw/T. Brown

Full

$42,030

Joel Moody

Ovarian Cancer Risk and Common Genetic Variants in Growth Factors and Steroid Hormone Metabolism:  An Epidemiological Study in the Ontario Population

J. McLaughlin

Full

$25,000

Victoria Pinto

Assessment of symptom benefit response to palliative chemotherapy in recurrent ovarian cancer patients and its relation to objective response – a prospective pilot study

A. Oza

Partial

$17,500

Kelly Seto

cDNA Microarray-Based Identification of Genes and Pathways in Familial Ovarian Cancer

Irene Andruilis

Full

$23,900

Katharine Sodek

Project Title:  Factors Affecting Invasive Behaviour of Ovarian Cancer Cells

T. Brown/

M. Ringuette

Full

$25,000

Jocelyn Stewart

In Search of the Ovarian Cancer Stem Cell

M. Letarte

Full

$25,000

Alicia Tone

The Study of Fallopian Tube Epithelium to Identify Early Events in Hereditary Serous Carcinogenesis

P. Shaw

Partial

$16,000

Gang Ye

Role of microRNA 368 on ovarian cancer cell proliferation and apoptosis

Chun Peng

Partial

$20,000

Total awarded

$227,430

Research Projects

Basic Research - Genetics

• Chromosomal profiling of ovarian cancer tumors to identify common areas of gain or loss.
• Gene expression profiling of ovarian cancers to identify key genes with altered expression associated with outcome and chemoresistance.
• Single nucleotide polymorphism analysis and prediction of response to chemotherapy.
• Ovarian cancer risk and variation in mismatch repair genes.
• Functional characterization of androgen-altered genes with a putative role during early events in ovarian carcinogenesis.

Basic Research - Proteomics

• Proteomics: relationship between specific protein products (of genes) and response to therapy.
• Inhibition of MT1-MMP in Ovarian Cancer; a strategy for therapeutic intervention.
• Protein microarray analysis of ovarian cancer to identify early disease markers.
• Integrated computational biology approach to marker selection for early detection and treatment of epithelial ovarian cancer.

Translational Research

• The Ontario-wide Familial Ovarian Tumour Study of the role of genetic and environmental factors in ovarian cancer susceptibility.
• Population-based association studies of genetic variants as modifiers of ovarian cancer risk.
• The role of genetic variation in the TGF-beta signaling pathway in clinical outcomes following ovarian cancer.
• Development of ovarian cancer tissue microarrays for target gene validation and for examining:
  • Expression of apoptosis related proteins in ovarian cancer, correlated with type, stage, and outcome
  • The predictive value of a novel protein TACC-1 in the response of ovarian cancer to taxane therapy
• Premalignant lesions of the fallopian tube as a potential source for serous ovarian cancer.