Home page Description:
FASEB SRC: Biological Methylation: Fundamentals in Health and Disease, Jun 19-24, 2016, Lisbon
Posted On: August 16, 2016
Image Caption:
Dr. Evelyne Lima-Fernandes, PDF
Supervisor: Dr. Cheryl Arrowsmith, PM
Abstract Title: EZH2 Regulates Colorectal Cancer-Initiating Cells Self-Renewal
Conference Highlight: The meeting focused on the epigenetic regulation of cell identity, development and cancer. Leaders in the field, junior investigators and trainees were invited to give short presentations about their work.
Conference Article: The FASEB SRC focusing on epigenetics is an international conference organized every two years, which attracts leaders in the field, junior investigators and trainees from different research areas who are interested in epigenetics. The conference presentations covered a broad range of subjects including the role of methylation in development and cell reprogramming, histone and non-histone methylation, DNA and RNA methylation, as well as the role of epigenetics in cancer. A striking feature of the 2016 meeting was the research community’s growing interest in protein arginine methyltransferases (PRMTs), particularly PRMT1, PRMT5 and PRMT7. For example, several presentations described PRMT5’s involvement in normal and cancer stem cell renewal in models of muscle regeneration, neurogenesis and acute myeloid leukemia. In a very interesting seminar, Dr. John Denu (University of Wisconsin) presented data suggesting that the effect that gut microbes have on human health may be due to changes in the epigenome. He showed that implanting bacterial communities into the colon of germ-free mice altered the epigenome in the colon, liver and adipose tissue, suggesting that the microbiome alters the epigenome locally but also in more distal areas. In his keynote lecture, Dr. Peter Jones (Van Andel Research Institute) described a new methodology developed by his group, called NOMe-seq, that simultaneously maps nucleosomal positioning and DNA methylation on individual DNA molecules. Combined with ChIP-seq, NOMe-seq gives a comprehensive view of chromatin states and structural alterations to chromatin in cancer.
Conference Highlight: The meeting focused on the epigenetic regulation of cell identity, development and cancer. Leaders in the field, junior investigators and trainees were invited to give short presentations about their work.
Conference Article: The FASEB SRC focusing on epigenetics is an international conference organized every two years, which attracts leaders in the field, junior investigators and trainees from different research areas who are interested in epigenetics. The conference presentations covered a broad range of subjects including the role of methylation in development and cell reprogramming, histone and non-histone methylation, DNA and RNA methylation, as well as the role of epigenetics in cancer. A striking feature of the 2016 meeting was the research community’s growing interest in protein arginine methyltransferases (PRMTs), particularly PRMT1, PRMT5 and PRMT7. For example, several presentations described PRMT5’s involvement in normal and cancer stem cell renewal in models of muscle regeneration, neurogenesis and acute myeloid leukemia. In a very interesting seminar, Dr. John Denu (University of Wisconsin) presented data suggesting that the effect that gut microbes have on human health may be due to changes in the epigenome. He showed that implanting bacterial communities into the colon of germ-free mice altered the epigenome in the colon, liver and adipose tissue, suggesting that the microbiome alters the epigenome locally but also in more distal areas. In his keynote lecture, Dr. Peter Jones (Van Andel Research Institute) described a new methodology developed by his group, called NOMe-seq, that simultaneously maps nucleosomal positioning and DNA methylation on individual DNA molecules. Combined with ChIP-seq, NOMe-seq gives a comprehensive view of chromatin states and structural alterations to chromatin in cancer.