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| Current Positions |
| since Oct 2002 |
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Scientist, Cancer Genomics and Proteomics , Ontario Cancer Institute,
University Health Network, Toronto, Canada |
| since Mar 2003 |
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Assistant professor, Department of Medical Biophysics, University of
Toronto, Toronto, Canada |
| Education |
| PhD 1994 |
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Department of Botany, University of Toronto, Toronto, Canada.
Thesis Title: Modeling the Evolution of RNA Secondary Structure:
Implications for Phylogenetic Analysis. |
| MSc 1988 * |
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Department of Biology, York University, Toronto, Canada.
Thesis Title: The Sampling Distribution of Alleles in Subdivided
Populations.
* Graduated with Distinction |
| BSc 1986 ** |
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Combined Honours, Biology and Applied Computational and Mathematical
Sciences, York University, Toronto, Canada
** Dean's List |
| Awards |
| 2006-2011 |
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Canada Research Chair (Tier II) in Analytical Genomics |
| 1994, 1995 |
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Natural Sciences and Engineering Research Council (NSERC) Post-Doctoral
Fellowship |
| 1991, 1992 |
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Ontario Graduate Scholarship |
| 1989, 1990 |
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Natural Sciences and Engineering Research Council (NSERC) Post-Graduate
Scholarship |
| 1988 |
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Best Thesis Prize, York University |
| Work Experience |
| Nov 2000 - Sept 2002 |
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Associate Scientist II. Clinical Genomics Centre, University Health
Network (Ontario Cancer Institute), Toronto. |
| Apr 1996 - Oct 2000 |
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Postdoctoral Fellow, Department of Molecular and Medical Genetics,
University of Toronto (Supervisor: Dr. Richard A. Collins) |
| Jan 1994 - Dec 1995 |
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NSERC Postdoctoral Fellow, Wadsworth Center for Laboratories and Research,
New York State Department of Health, Albany, NY, USA (Supervisor: Dr. Marlene
Belfort) |
| May 1989 - Jan 1994 |
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PhD Candidate: Department of Botany, University of Toronto (Supervisor:
Dr. Richard A. Collins) |
| Sept 1986 - Sept 1988 |
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MSc Candidate: York University, Toronto (Supervisor: Dr. G. Brian Golding) |
| June 1985 - Aug 1985 |
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Research Apprentice, Centre international de coopération en
recherche agronomique (CIRAD), Montpelier, France |
| Summers 1982-1985 |
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Computer Programmer, Palmindustrie, Abidjan, Ivory Coast |
| Memberships |
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Associate of the Canadian Institute for Advanced Research (CIAR), Evolutionary
Biology Program (2002-2006) |
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Faculty member of the University of Toronto Proteomics and Bioinformatics
Collaborative Graduate Program |
| Grant Funding |
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Models of sequence evolution and applications for comparative sequence analysis (NSERC Discovery grant) |
|
Period |
2006-04-01 to 2011-03-31 |
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Principal Investigator |
TILLIER, Elisabeth Renee |
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In silico prediction of protein interaction networks (CIHR Operating grant) |
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Period |
2004-04-01 to 2007-03-31 |
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Principal Investigator |
TILLIER, Elisabeth Renee |
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Genomic and RNomic analysis of novel mouse transcriptional
regulators (CIHR Operating grant) |
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Period |
2004-04-01 to 2007-03-31 |
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Principal Investigators |
FREY, Brendan John; HUGHES, Timothy Richard |
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Co-Investigator |
TILLIER, Elisabeth Renee |
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The role of non-coding conserved regions in RB1 gene
regulation and initiation of retinoblastoma (CIHR Operating grant) |
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Period |
2003-10-01 to 2006-09-30 |
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Principal Investigator |
GALLIE, Brenda Louise |
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Co-Investigators |
DROUIN, Régen; TILLIER, Elisabeth Renée; WASSERMAN, Wyeth
Wyk |
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Development and applications of functional genomics
technologies (Ontario Genomics Institute) |
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Period |
2002 to 2005 |
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Principal Investigator |
WOODGETT, James |
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Co-Investigators |
PENNINGER, J.; JURISICA, I.; MANOUKIAN, A.; MACGREGOR, P.; TAKAHASHI,
M.; TILLIER, E. |
| Publications |
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Feng, S. and E.R.M. Tillier. (2007) A fast and flexible approach to oligonucleotide probe design
for genomes and gene families. Bioinformatics 23:1195-1202. |
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Wang, Z., Tillier, E.R.M., (2007) Aligning Two RNA
Secondary Structures with l-Block, Biomolecular Engineering,
doi:10.1016/j.bioeng.2007.02.004 |
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Nuin PAS., Wang Z., and E.R.M. Tillier. (2006) The accuracy of several multiple sequence alignments for proteins. BMC Bioinformatics 7:471. |
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Wang, Z. and E.R.M. Tillier. (2006) A Bayesian approach to pairwise RNA Secondary Structure Alignment. Computational Intelligence and Bioinformatics and Computational Biology, 2006. CIBCB '06. 2006 IEEE Symposium on , vol., no., pp.1-8, 28-29 Sept. 2006 |
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Tillier, E. R. M, G. Li, D. Tillo and DL. Biro (2006) Maximizing co-evolutionary interdependencies to discover interacting proteins. PROTEINS: Structure, function and Bioinformatics 63(4):822-31. |
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Burgetz IJ, Shariff S., Pang A. and ERM Tillier (2006). Positional homology in bacterial genomes. Evolutionary Bioinformatics Online 2:46-55. |
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Pang, A., Smith, A. Nuin, PAS and E.R.M Tillier. (2005) SIMPROT:
Using an empirically determined Indel distribution in simulations of protein
evolution. BMC Bioinformatics: 6:236. |
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Esrem E. and E. R. M Tillier. (2005) Genome Rearrangement and Planning.
In Proceedings of the Twentieth National Conference on Artificial Intelligence (AAAI’05),
pages 1139–1144, 2005. |
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Bishop RE., Cambillau, C., Privé, G.G., His D., Tillo, D., and
E. R. M. Tillier (2005) Bacterial lipocalins: Origin, Structure,
and Function. In Akerström B, Borregaard, N, Flower DR, Salier
JP (eds), Lipocalins, Landes Bioscience. |
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Sankoff, D., Lefebvre, J-F, Tillier, E. Maler, A. and N. El-Mabrouk
(2004) The distribution of inversion lengths in bacteria. Lecture Notes
in Computer Science 3388: 97 -101. |
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Smith, A., Lui, T. W. H. and Tillier, E. R. M. (2004) Empirical substitution
models for Ribosomal RNA. Mol. Biol. Evol. 21: 419-427 |
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Veerassamy, S., Smith A. and Tillier, E. R. M. (2003) A transition
probability model for amino acid substitutions from BLOCKS. Journal
of Computational Biology 10(6): 997-1010 |
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Lui, T. W. H. and Tillier, E. R. M. (2003) Finding the functional
amino acid associations with and without assuming the protein sequence
phylogeny. Proceedings, Joint Conference on Information
Science (2003) 855-856 |
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Tillier, E. R. M. and Lui, T. W. H. (2003) Using multiple interdependency
to separate functional from phylogenetic correlations in protein alignments.
Bioinformatics 19:750-755 |
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Lefebvre J.-F., El Mabrouk, N., Tillier, E. R. M. and Sankoff,
D. (2003) Detection and validation of single gene inversions. Bioinformatics
19(Suppl 1):I190-I196 |
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Ajana Y., Lefebvre J.-F., Tillier, E. R. M. and El Mabrouk, N.
(2002) Exploring the set of all minimal sequences of reversals - An application
to test the replication-directed reversal hypothesis. In R. Guigo and D.
Gusfeild, editors, Algorithms in BioInformatics, Second International
Workshop, WABI, volume 2452 of Lecture Notes in Computer Sciences,
pages 300-315 |
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Tillier, E. R. M. and Collins, R. A. (2000) Replication Orientation
affects the rate and direction of bacterial gene evolution. J. Mol.
Evol. 51:459-463 |
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Tillier, E. R. M. and Collins, R. A. (2000) Genome Rearrangement by
Replication-Directed Translocation. Nature Genetics 26:195-197 |
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Tillier, E. R. M. and Collins, R. A. (2000) The Contributions of Replication
orientation, Transcription Orientation and Signal Sequences to Base-Composition
Asymmetries in Prokaryotic Genomes. J. Mol. Evol., 50:249-257 |
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Tillier, E. R. M. and Collins, R. A. (1998) High apparent rate of simultaneous
compensatory base-pair substitutions in ribosomal RNA. Genetics
148:1993-2002 |
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Tillier, E. R. M. and R. A. Collins (1995). Neighbor-Joining and Maximum Likelihood with RNA Sequences: Addressing the Inter-dependence of Sites. Mol. Biol. Evol. 12:7-15. |
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Loizos, N., E. R. M. Tillier and M. Belfort (1994). Evolution of Mobile Group I Introns: Recognition of Intron Sequences by an Intron-Encoded Endonuclease. Proc. Natl. Acad. Sci. USA 91:11983-11987. |
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Tillier, E. R. M. (1994). Maximum Likelihood with Multiparameter Models of Substitution. J. Mol. Evol. 39:409-417. |
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Guo, C. T., D. M. De Abreu, E. R. M. Tillier, B. J. Saville, J. E. Olive and R. A. Collins (1992). Nucleotide Sequence Requirements for Self-cleavage of Neurospora VS RNA. J. Mol. Biol. 232:351-361. |
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Tillier, E. R. M. and G. B. Golding (1989). Homozygosity of Selected Alleles in Subdivided Populations. Theor. Pop. Biol. 36:59-76 . |
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Tillier, E. R. M. and G. B. Golding (1988). A Sampling Theory of Selectively Neutral Alleles in a Subdivided Population. Genetics 119:721-729. |
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