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Brenda L. Gallie, Ph.D. Professor, University of Toronto Head Cancer Informatics Ontario Cancer Institute/ Princess Margaret Hospital University Health Network RM 8-415, 610 University Avenue Toronto M5G 2M9 Phone: 416-946-2324 Email: gallie@attglobal.net |
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Research Interest The rare tumor, retinoblastoma, arises in the retina of children when both alleles of the RB1 gene are mutated. We determine the RB1 mutations in retinoblastoma probands and use that data to diagnose tumors before birth. We are initiating world clinical trials to optimize therapy. To understand why loss of the RB1 gene causes retinoblastoma in children, we are defining the precise time when the gene is expressed in the few types of retinal cells that depend on it to terminally differentiate. We have recently cloned a novel potential oncogene, RBKIN, which may which contribute to retinoblastoma initiation. Our long-term goal is to use the results of our research to block the development of tumors caused by RB1 mutations. |
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Recent Publications Richter S, Vandezande K, Chen N, Zhang K, Sutherland J, Anderson J, Han L, Panton R, Branco P, Gallie B. Sensitive and Efficient Detection of RB1 Gene Mutations Enhances Care for Families with Retinoblastoma. Am J Hum Genet. 2003 Feb;72(2):253-69. Du C, Jiang Y, Gallie BL. Low-penetrance retinoblastoma due to exons 24 and 25 deletions in the Rb1 gene Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Oct;19(5):370-4. Chinese. Valverde K, Pandya J, Heon E, Goh TS, Gallie BL, Chan HS. Retinoblastoma with central retinal artery thrombosis that mimics extraocular disease. Med Pediatr Oncol. 2002 Apr;38(4):277-9. Pandya J, Valverde K, Heon E, Blaser S, Gallie BL, Chan HS. Predilection of retinoblastoma metastases for the mandible. Med Pediatr Oncol. 2002 Apr;38(4):271-3. Watts P, Westa C, Colpa L, MacKeen L, Abdolell M, Gallie B, Heon E. Visual results in children treated for macular retinoblastoma. Eye. 2002 Jan;16(1):75-80. Vincent AL, Webb MC, Gallie BL, Heon E. Prosthetic conformers: a step towards improved rehabilitation of enucleated children. Clin Experiment Ophthalmol. 2002 Feb;30(1):58-9. Chen D, Pajovic S, Duckett A, Brown VD, Squire JA, Gallie BL. Genomic amplification in retinoblastoma narrowed to 0.6 megabase on chromosome 6p containing a kinesin-like gene, RBKIN.Cancer Res. 2002 Feb 15;62(4):967-71. Brown VD, Gallie BL. The B-domain lysine patch of pRB is required for binding to large T antigen and release of E2F by phosphorylation. Mol Cell Biol. 2002 Mar;22(5):1390-401. Gonzalez EG, Steeves JK, Kraft SP, Gallie BL, Steinbach MJ. Foveal and eccentric acuity in one-eyed observers. Behav Brain Res. 2002 Jan 7;128(1):71-80. |
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