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Research Interests
- Fragment screening library
- Novel Targets for Structure Determination
Selected Publications
X-ray structure
of the Staphylococcus aureus putative
ATPase subunit of an ATP-binding cassette (ABC) transporter (2007) to be submitted.
Robert Lam, Vladimir Romanov, Kathy Johns, Kevin Battaile, Jean
Wu-Brown, Robert P. Hausinger, Emil Pai, and Nickolay Y. Chirgadze.
Structure of the Helicobacter pylori Urease Accessory Protein UreF 2010
PROTEINS: Structure, Function, and Bioinformatics
Cardarelli, L., Lam, R. Tuite, A., Baker, L. A., Sadowski, P. D.,
Radford, D. R., Rubinstein, J. L., Battaile, K. P., Chirgadze, N., Maxwell,
K. L., and Davidson, A. R. 2009. The X-Ray Crystal Structure of
Bacteriophage HK97 gp6: Defining a Large Family of Head-Tail Connector
Proteins. J Mol Biol [epub ahead of print].
Singer AU, Rohde JR, Lam R, Skarina T, Kagan O, Dileo R, Chirgadze NY,
Cuff ME, Joachimiak A, Tyers M, Sansonetti PJ, Parsot C, Savchenko A.
Structure of the Shigella T3SS effector IpaH defines a new class of E3
ubiquitin ligases. Nature Structural & Molecular Biology 2008 15, 1293 -
1301
Savchenko A, Michael, Tatiana Skarina, Alexander Singer, Olga Litvinova,
Ruslan Sanishvili, Greg Brown, Chirgadze NY, Alexander F. Yakunin Molecular
Basis of the Antimutagenic Activity of the House-Cleaning Inosine
Triphosphate Pyrophosphatase RdgB from Escherichia coli J Mol Biol. 2007 Dec
7;374(4):1091-103
Mochalkin I, Lightle S, Zhu Y, Ohren J, Spessard C, Chirgadze NY,
Banotai C, Melnik M, McDowell L. Characterization of substrate binding and
catalysis in the potential antibacterial target
N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) Protein Science
2007, 16: 2657-2666
Klimkowski VJ, Watson BM, Wiley MR, Liebeschuetz J, Franciskovich JB,
Marimuthu J, Bastian JA, Sall DJ, Smallwood JK, Chirgadze NY, Smith GF,
Foster RS, Craft T, Sipes P, Chastain M, Sheehan SM.
D-phenylglycinol-derived non-covalent factor Xa inhibitors: effect of
non-peptidic S4 linkage elements on affinity and anticoagulant activity.
Bioorg Med Chem Lett. 2007 Nov 1;17(21):5801-5. Epub 2007 Aug 28.
Wang Y, Chirgadze NY, Briggs SL, Khan S, Jensen EV, Burris TP. Related A
second binding site for hydroxytamoxifen within the coactivator-binding
groove of estrogen receptor beta. PNAS 2006 Jun 27; 103(26), 9908-11
Selected Abstracts
Roni Gordon, Robert Lam, Jakub Vodsedalek, Kevin Battaile, Vladimir
Romanov, Kim Lam, Irina Beletskaya, Andrew Scotter, Robert Rottapel, Emil
Pai, and Nickolay Chirgadze. Zinc-binding catalytic PARP domain of human
tankyrase 2. P-T110 American Crystallographic Association Meeting July
25-30, 2009, Toronto, Canada
Robert Lam, Vladimir Romanov, Kathy Johns, Kevin Battaile, Jean
Wu-Brown, Jennifer Guthrie, Robert P. Hausinger, Emil Pai, and Nickolay
Chirgadze. Structure of the Helicobacter pylori Urease Accessory Protein
UreF. P-M008 American Crystallographic Association Meeting July 25-30, 2009,
Toronto, Canada
Kevin P. Battaile, Robert Lam, Tara Davis, Lisa Keefe, Emil F. Pai,
Nickolay Y. Chirgadze. Studying the Feasibility of Sulfur Phasing for de
novo Structure Solution at the Highly Automated Facilities of the IMCA-CAT
Beamline. P-T062 American Crystallographic Association Meeting July 25-30,
2009, Toronto, Canada
Nickolay Chirgadze, Robert Lam, Kevin Battaile, Roni Gordon, Gera
Kisselman,
Jennifer Artz, Raymond Hui, Lisa Keefe, Cheryl Arrowsmith, Emil Pai.
Identification of novel fragment-based hits for Plasmodium berghei orotidine
5'-monophosphate decarboxylase
IUCr 2008, Osaka, Japan XXI Congress of international Union of
Crystallographers, Abstract No. 90792
Robert Lam, Kevin Battaile, Roni Gordon, Gera Kisselman, Jennifer Artz,
Raymond Hui, Cheryl Arrowsmith, Emil Pai, and Nickolay Chirgadze
Identification of a Novel Class of Nitropyrazole Hits for Plasmodium berghei
Orotidine 5'-Monophosphate Decarboxylase using Fragment-Based Screening by
X-ray Crystallography Approach Fragment-based Lead Discovery 2008 San Diego
February 17-20, 2008
Patents/Patent Applications
Chirgadze NY, Miller J, Lam R, Johns K. Crystallization Device for
High-Thoughput Visual inspection and X-ray Diffraction Analysis. WO
2009/073972 A1 International Publication Date 18: June 2009
Structure Gallery
2IHY - Structure
of the Staphylococcus aureus putative
ATPase subunit of an ATP-binding cassette (ABC) transporter
2OBA
- Crystal
structure of Pseudomonas
aeruginosa (probable)
6-pyruvoyl tetrahydrobiopterin synthase
determined at 2.4 Å resolution
2NWQ - Crystal structure of Pseudomonas
aeruginosa short chain dehydrogenase of unknown function at 2.3 Å resolution
2O1B - Crystal structure of Staphylococcus
aureus aspartate aminotransferase at 1.95 Å resolution
2O4D - Crystal structure of a
hypothetical protein from
Pseudomonas
aeruginosa
solved by SAD at 1.85 Å resolution
3K2A - Crystal structure of the homeobox domain of human homeobox protein Meis2
3KBY - Crystal structure of hypothetical protein from Staphylococcus aureus
3KOR - Crystal structure of a putative Trp repressor from Staphylococcus aureus
3KWL - Crystal structure of a hypothetical protein from Helicobacter pylori
3L5A - Crystal structure of a probable NADH-dependent flavin oxidoreductase from Staphylococcus aureus
3L20 - Crystal structure of a hypothetical protein from Staphylococcus aureus
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