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Ontario Cancer Institute Toronto General Research Institute Toronto Rehabilitation Institute Toronto Western Research Institute
  • Located at the Princess Margaret Cancer Centre, Toronto, Ontario
  • Research foci: cancer— genomics, informatics, molecular biology, clinical trials, signalling pathways, structural biology and biophysics.
  • 361 scientists and clinician-scientists
  • $162M external funding
  • more
  • Located at the Toronto General Hospital, Toronto, Ontario
  • Research foci: cardiology, transplantation, immunology and infectious disease
  • 230 scientists and clinician-scientists
  • $73M external funding
  • more
  • Located at Toronto Rehab, Toronto, Ontario
  • Research foci: rehabilitation sciences, cardiopulmonary fitness and mobility
  • 119 scientists and clinician-scientists
  • $8M external funding
  • more
  • Located at the Toronto Western Hospital, Toronto, Ontario
  • Research foci: Neural and visual sciences, musculoskeletal disease and community and population health
  • 159 scientists and clinician-scientists
  • $35M external funding
  • more


Malaria: Bad Blood and Collateral Damage
Apr 25, 2014

Of all diseases, malaria represents one of the greatest global health threats. Its most severe form, known as cerebral malaria, occurs when blood cells infected with the malaria parasite accumulate in the brain and block blood flow, leading to tissue damage—a condition that is particularly devastating in children, as it can lead to death in 20% of those infected and long-term brain damage in those that survive.

TGRI Senior Scientist Dr. Kevin Kain and Assistant Scientist Dr. Lena Serghides are exploring a promising new class of compounds to treat cerebral malaria, known as PPAR-gamma (Peroxisome proliferator-activated receptor-gamma) agonists. While preliminary evidence suggests that these compounds may promote the body's ability to clear infected blood cells and reduce harmful inflammation, it is still unclear at the molecular level how these drugs may act to protect brain tissues.

Full Story

McEwen Monthly April Issue
Apr 25, 2014

The McEwen Monthly is now available online! This month’s issue highlights a study by McEwen Researcher Dr. Andras Nagy that examines a potential new therapy capable of targeting abnormal blood vessel growth in retinal disorders such as diabetic retinopathy and age-related macular degeneration.

To read these stories and more, click here.

Full Story

March Issue of TrialScribe Now Available
Apr 23, 2014

TrialScribe is a bi-monthly e-newsletter devoted to highlighting the latest clinical research news and events at UHN.

Read the March issue to learn more about:

  • An early palliative care program that may improve the wellbeing of terminally ill cancer patients
  • A more effective treatment for mesothelioma, a type of cancer caused by asbestos
  • UHN requirements for retaining data and records in clinical research
  • UHN’s new online system for the long-term storage of research data
  • PM Cancer Centre’s “Advances in Personalized Cancer Medicine” Conference

Follow this link to read TrialScribe now.

Full Story


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